Targeting TMEM16A to reverse vasoconstriction and remodelling in idiopathic pulmonary arterial hypertension

Papp Rita; Nagaraj Chandran; Zabini Diana; Nagy Bence M.; Lengyel Miklos; Maurer Davor Skofic; Sharma Neha; Egemnazarov Bakytbek; Kovacs Gabor; Kwapiszewska Grazyna; Marsh Leigh M.; Hrzenjak Andelko; Hoefler Gerald; Didiasova Miroslava; Wygrecka Malgorzata; Sievers Laura K.; Szucs Peter; Enyedi Peter; Ghanim Bahil; Klepetko Walter; Olschewski Horst; Olschewski Andrea

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Targeting TMEM16A to reverse vasoconstriction and remodelling in idiopathic pulmonary arterial hypertension

机译：靶向TMEM16a以反转血管收缩性肺动脉高压的血管收缩和重塑

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Our systematic analysis of anion channels and transporters in idiopathic pulmonary arterial hypertension (IPAH) showed marked upregulation of the Cl- channel TMEM16A gene. We hypothesised that TMEM16A overexpression might represent a novel vicious circle in the molecular pathways causing pulmonary arterial hypertension (PAH).

机译：我们对特发性肺动脉高血压（IPAH）的阴离子通道和转运蛋白的系统分析显示出显着上调的Cl通道TMEM16A基因。我们假设TMEM16a过表达可能代表分子途径中的新型恶性圆圈，导致肺动脉高血压（PAH）。

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《The European respiratory journal : 》 |2019年第6期| 共13页
作者
Papp Rita; Nagaraj Chandran; Zabini Diana; Nagy Bence M.; Lengyel Miklos; Maurer Davor Skofic; Sharma Neha; Egemnazarov Bakytbek; Kovacs Gabor; Kwapiszewska Grazyna; Marsh Leigh M.; Hrzenjak Andelko; Hoefler Gerald; Didiasova Miroslava; Wygrecka Malgorzata; Sievers Laura K.; Szucs Peter; Enyedi Peter; Ghanim Bahil; Klepetko Walter; Olschewski Horst; Olschewski Andrea;
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作者单位

Ludwig Boltzmann Inst Lung Vasc Res Graz Austria;

Ludwig Boltzmann Inst Lung Vasc Res Graz Austria;

Ludwig Boltzmann Inst Lung Vasc Res Graz Austria;

Ludwig Boltzmann Inst Lung Vasc Res Graz Austria;

Semmelweis Univ Fac Med Dept Physiol Budapest Hungary;

Med Univ Graz Dept Physiol Graz Austria;

Ludwig Boltzmann Inst Lung Vasc Res Graz Austria;

Ludwig Boltzmann Inst Lung Vasc Res Graz Austria;

Ludwig Boltzmann Inst Lung Vasc Res Graz Austria;

Ludwig Boltzmann Inst Lung Vasc Res Graz Austria;

Ludwig Boltzmann Inst Lung Vasc Res Graz Austria;

Ludwig Boltzmann Inst Lung Vasc Res Graz Austria;

Med Univ Graz Dept Pathol Graz Austria;

Univ Giessen Dept Biochem Giessen Germany;

Univ Giessen Dept Biochem Giessen Germany;

Univ Clin Munster Med Clin D Munster Germany;

Univ Debrecen Dept Anat Histol &

Embryol Debrecen Hungary;

Semmelweis Univ Fac Med Dept Physiol Budapest Hungary;

Med Univ Vienna Dept Surg Div Thorac Surg Vienna Austria;

Med Univ Vienna Dept Surg Div Thorac Surg Vienna Austria;

Med Univ Graz Dept Internal Med Div Pulmonol Graz Austria;

Ludwig Boltzmann Inst Lung Vasc Res Graz Austria;

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正文语种 eng
中图分类呼吸系及胸部疾病 ;
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1. Targeting TMEM16A to reverse vasoconstriction and remodelling in idiopathic pulmonary arterial hypertension [J] . Papp Rita, Nagaraj Chandran, Zabini Diana, The European respiratory journal : . 2019 ,第6期

机译：靶向TMEM16a以反转血管收缩性肺动脉高压的血管收缩和重塑
2. Right ventricular reverse remodelling in Idiopathic Pulmonary Arterial Hypertension diagnosed during pregnancy: Is it possible? [J] . Giuseppe Paciocco, Andrea Lombi, Antonella Vincenzi, Respiratory Medicine Case Reports . 2017 ,第1期

机译：在怀孕期间诊断出特发性肺动脉高压的右心室反向重塑：是否有可能？
3. The principal pathways involved in the invivo modulation of hypoxic pulmonary vasoconstriction, pulmonary arterial remodelling and pulmonary hypertension [J] . Kylhammar D., Radegran G. Acta physiologica . 2017 ,第4期

机译：缺氧肺血管收缩，肺动脉重塑和肺动脉高压患者的主途径
4. Automated Assessment of Aortic and Main Pulmonary Arterial Diameters using Model-Based Blood Vessel Segmentation for Predicting Chronic Thromboembolic Pulmonary Hypertension in Low-Dose CT Lung Screening [C] . Hidenobu Suzuki, Yoshiki Kawata, Noboru Niki, SPIE Medical Imaging Conference . 2018

机译：使用基于模型的血管分割自动评估主动脉和主要肺动脉直径，以预测低剂量CT肺筛查中的慢性血栓栓塞性肺动脉高压
5. ATP and serotonin effects on vascular resistance and mitogenic pathways in broilers susceptible to idiopathic pulmonary arterial hypertension [D] . Stafford, Jesse A. 2011

机译：ATP和5-羟色胺对特发性肺动脉高压敏感肉鸡血管阻力和促有丝分裂途径的影响
6. Right ventricular reverse remodelling in Idiopathic Pulmonary Arterial Hypertension diagnosed during pregnancy: Is it possible? [O] . Giuseppe Paciocco, Andrea Lombi, Antonella Vincenzi, 2017

机译：妊娠期间诊断为特发性肺动脉高压的右心室反向重塑：可能吗？
7. Targeting TMEM16A to reverse vasoconstriction and remodelling in idiopathic pulmonary arterial hypertension [O] . Rita Papp, Chandran Nagaraj, Diana Zabini, 2019

机译：靶向TMEM16A在特发性肺动脉高压下反转血管收缩和重塑

Targeting TMEM16A to reverse vasoconstriction and remodelling in idiopathic pulmonary arterial hypertension

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