Successful use of Bruton's kinase inhibitor, ibrutinib, to control paraneoplastic pemphigus in a patient with paraneoplastic autoimmune multiorgan syndrome and chronic lymphocytic leukaemia

摘要

Abstract We present the case of a 51‐year‐old man who developed paraneoplastic pemphigus ( PNP ) in the context of chronic lymphocytic leukemia ( CLL ). His CLL was successfully controlled with ibrutinib. Concurrently, there was significant improvement of his PNP , suggesting that ibrutinib may be a very useful addition to the treatment options in this potentially life‐threatening autoimmune disorder.