Novel Survivin-Targeted Small Interfering RNA Delivered by Nanoparticles

Feng Chen; Wang Tianyou; Zhang Yi; Qu Kuiyao; Tang Suoqin

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Novel Survivin-Targeted Small Interfering RNA Delivered by Nanoparticles

机译：纳米颗粒递送的新型Survivin-靶向小干扰RNA

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摘要

Background: The aim of the present study was to investigate the antitumor effect of our novel survivin-targeted small interfering RNA (siRNA) nanoliposomes on xenograft mouse models with human cervical carcinoma HeLa cells, and to evaluate pharmacokinetics.

机译：背景：本研究的目的是探讨我们的新型Survivin-靶向小干扰RNA（siRNA）纳米脂质体对卵转移小鼠模型与人宫颈癌Hela细胞的抗肿瘤效应，并评估药代动力学。

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来源
《The American Journal of the Medical Sciences》 |2017年第5期|共7页
作者
Feng Chen; Wang Tianyou; Zhang Yi; Qu Kuiyao; Tang Suoqin;
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作者单位

Chinese Peoples Liberat Army Gen Hosp Dept Pediat 28 Fuxing Rd Beijing 100853 Peoples R China;

Capital Med Univ Beijing Childrens Hosp Dept Hematol Oncol Beijing Peoples R China;

Capital Med Univ Beijing Tongren Hosp Dept Pediat Beijing Peoples R China;

Chinese Peoples Liberat Army Gen Hosp Dept Pediat 28 Fuxing Rd Beijing 100853 Peoples R China;

Chinese Peoples Liberat Army Gen Hosp Dept Pediat 28 Fuxing Rd Beijing 100853 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Survivin; siRNA; Nanoliposome; Human cervical carcinoma cells; Pharmacokinetics;

机译：Survivin;siRNA;纳米脂质体;人宫颈癌细胞;药代动力学;

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专利

1. Novel Survivin-Targeted Small Interfering RNA Delivered by Nanoparticles [J] . Feng Chen, Wang Tianyou, Zhang Yi, The American Journal of the Medical Sciences . 2017,第5期

机译：纳米颗粒递送的新型Survivin-靶向小干扰RNA
2. Hydrophobic scaffolds of pH-sensitive cationic lipids contribute to miscibility with phospholipids and improve the efficiency of delivering short interfering RNA by small-sized lipid nanoparticles [J] . Sato Yusuke, Okabe Nana, Note Yusuke, Acta biomaterialia . 2020,第期

机译：pH敏感阳离子脂质的疏水性支架有助于磷脂的混溶性，提高小型脂质纳米颗粒输送短干扰RNA的效率
3. Dual-Targeting Nanoparticle-Mediated Gene Therapy Strategy for Hepatocellular Carcinoma by Delivering Small Interfering RNA [J] . Zheng Qi Chang, Jiang Shuai, Wu Yu Zhe, Frontiers in Bioengineering and Biotechnology . 2020,第1期

机译：通过输送小干扰RNA，双靶向纳米粒子介导的肝细胞癌的基因治疗策略
4. Oligoethylene glycol mediates knockdown effect of small interfering RNAs conjugated goldnanoparticles [C] . Madhusudhan R. Papasani, Deep Pokharel, Anjil Giri, NSTI-Nanotech 2010;NSTI nanotechnology conference and expo;Bio Nanotech 2010;NSTI bio nano conference and expo;Microtech 2010;Microtechnology conference and expo;WCM 2010;Workshop on compact modeling;NSTI nanotech ventures;TechConnect summit;Clean technology . 2010

机译：寡聚乙二醇介导小干扰RNA共轭金纳米颗粒的敲低效应
5. Espression of Caenorhabditis elegans small interfering RNAs depends on MUT-16 and the pathway of nonsense-mediated mRNA decay [D] . Frater-Rubsam, Leah 2011

机译：秀丽隐杆线虫小干扰RNA的表达取决于MUT-16和无意义介导的mRNA衰变的途径
6. Corrigendum: Dual-Targeting Nanoparticle-Mediated Gene Therapy Strategy for Hepatocellular Carcinoma by Delivering Small Interfering RNA [O] . Qi Chang Zheng, Shuai Jiang, Yu Zhe Wu, 2021

机译：勘误：通过输送小干扰RNA双靶向纳米粒子介导的肝细胞癌的基因治疗策略
7. Inhibiting recycling pathways to enhance cellular retention of lipid nanoparticle (LNP)-delivered small interfering RNAs [O] . 2013

机译：抑制回收途径，以增强脂质纳米粒子（LNP）的细胞保留 - 驱动小干扰RNA

Novel Survivin-Targeted Small Interfering RNA Delivered by Nanoparticles

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