Correlations of MicroRNA-21 Gene Polymorphisms With Chemosensitivity and Prognosis of Cervical Cancer

摘要

BackgroundWe investigated correlations of miR-21 gene polymorphisms including rs1292037 (A > G) and rs13137 (A > T) with the chemosensitivity to cisplatin plus paclitaxel, and prognosis before cervical cancer (CC) surgery, which may provide a novel target for prevention and treatment of CC. Materials and MethodsA total of 165 patients with CC were divided into 2 groups, a sensitive group and resistance group. Gene polymorphisms of rs1292037 (A > G) and rs13137 (A > T) were detected respectively. Logistic and Cox multivariate regression analyses were used to explore factors that influence resistance to cisplatin plus paclitaxel. Resultsrs1292037 (A > G) locus AG, GG, AG?+?GG and G allele in miR-21 gene may increase chemoresistance to cisplatin plus paclitaxel in CC. The risk factors of prognosis included rs1292037 (A > G) locus, tumor stage, maximum lesion diameter and lymph node metastasis (hazard ratio [HR]?=?1.819, 95% CI?=?1.127-2.935; HR?=?1.504, 95% CI?=?1.070-2.114; HR?=?1.671, 95% CI?=?1.038-2.689; HR?=?3.043, 95% CI?=?1.783-5.193). The influencing factors of resistance to cisplatin plus paclitaxel included maximum lesion diameter, tumor stage, lymph node metastasis and rs1292037 (odds ratio [OR]?=?14.047, 95% CI?=?5.694-34.653; OR?=?5.873, 95% CI?=?3.104-11.110; OR?=?3.574, 95% CI?=?1.554-8.216; OR?=?2.449, 95% CI?=?1.052-5.705). Conclusionsrs1292037 (A > G) locus are associated with the chemoresistance to cisplatin plus paclitaxel and prognosis of patients with CC. In addition to that, the G allele at rs1292037 (A > G) locus increases the risk of preoperative chemoresistance to cisplatin plus paclitaxel and is a poor prognostic factor for patients with CC.