MSI status is associated with distinct clinicopathological features in BRAF mutation colorectal cancer: A systematic review and meta-analysis

Wu Moxin; Kim Yong Sung; Ryu Han-Seung; Choi Suck Chei; Kim Keun Young; Park Won Cheol; Kim Min Seob; Myung Ji Yeon; Choi Hyun Seok; Kim Eui Joong; Lee Moon Young

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MSI status is associated with distinct clinicopathological features in BRAF mutation colorectal cancer: A systematic review and meta-analysis

机译：MSI状态与BRAF突变结直肠癌中的不同临床病理特征有关：系统审查和荟萃分析

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Background: Microsatellite stable (MSS) BRAF p.V600E mutation colorectal cancer (BRAF-CRC) has a poor prognosis, whereas microsatellite instability (MSI) in BRAF-CRC is associated with a favorable prognosis. Although usually considered a single clinical entity, the MSI BRAF-CRC subtype shows some distinct characteristics in comparison with the MSS BRAF-CRC subtype.

机译：背景：微卫星稳定（MSS）BRAF P.V600E突变结直肠癌（BRAF-CRC）预后差，而BRAF-CRC中的微卫星不稳定性（MSI）与良好的预后有关。虽然通常被认为是单一的临床实体，但MSI BRAF-CRC亚型显示与MSS BRAF-CRC亚型相比的一些不同的特性。

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来源
《Pathology Research and Practice》 |2020年第1期|共8页
作者
Wu Moxin; Kim Yong Sung; Ryu Han-Seung; Choi Suck Chei; Kim Keun Young; Park Won Cheol; Kim Min Seob; Myung Ji Yeon; Choi Hyun Seok; Kim Eui Joong; Lee Moon Young;
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作者单位

Jiujiang Univ Affiliated Hosp Dept Med Lab Jiujiang 332000 Peoples R China;

Wonkwang Univ Sch Med Wonkwang Digest Dis Res Inst Dept Gastroenterol Iksan 54538 South Korea;

Wonkwang Univ Sch Med Wonkwang Digest Dis Res Inst Dept Gastroenterol Iksan 54538 South Korea;

Wonkwang Univ Sch Med Wonkwang Digest Dis Res Inst Dept Gastroenterol Iksan 54538 South Korea;

Wonkwang Univ Sch Med Wonkwang Digest Dis Res Inst Dept Gen Surg Iksan 54538 South Korea;

Wonkwang Univ Sch Med Wonkwang Digest Dis Res Inst Dept Gen Surg Iksan 54538 South Korea;

Wonkwang Univ Sch Med Wonkwang Digest Dis Res Inst Dept Physiol Iksan 54538 South Korea;

Wonkwang Univ Sch Med Wonkwang Digest Dis Res Inst Dept Physiol Iksan 54538 South Korea;

Wonkwang Univ Sch Med Wonkwang Digest Dis Res Inst Dept Physiol Iksan 54538 South Korea;

Wonkwang Univ Sch Med Wonkwang Digest Dis Res Inst Dept Physiol Iksan 54538 South Korea;

Wonkwang Univ Sch Med Wonkwang Digest Dis Res Inst Dept Physiol Iksan 54538 South Korea;

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原文格式 PDF
正文语种 eng
中图分类病理学;
关键词
BRAF p.V600E mutation; Colorectal cancer; Microsatellite instability; Microsatellite stable; Clinicopathological features;

机译：BRAF P.V600E突变;结肠直肠癌;微卫星不稳定性;微卫星稳定;临床病理特征;

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专利

1. MSI status is associated with distinct clinicopathological features in BRAF mutation colorectal cancer: A systematic review and meta-analysis [J] . Wu Moxin, Kim Yong Sung, Ryu Han-Seung, Pathology Research and Practice . 2020,第1期

机译：MSI状态与BRAF突变结直肠癌中的不同临床病理特征有关：系统审查和荟萃分析
2. Clinicopathologic features and prognostic value of KRAS KRAS , NRAS NRAS and BRAF BRAF mutations and DNA mismatch repair status: A single‐center retrospective study of 1,834 Chinese patients with Stage I–IV colorectal cancer [J] . Guo Tian‐An, Wu Yu‐Chen, Tan Cong, International Journal of Cancer =: Journal International du Cancer . 2019,第6期

机译：KRAS KRAS，NRAS NRAS和BRAF BRAF突变和DNA错配修复状态的临床病理特征及预后价值：1,834例中国阶段I-IV型结直肠癌患者的单中心回顾性研究
3. Prognostic role and clinicopathological features of SMAD4 gene mutation in colorectal cancer: a systematic review and meta-analysis [J] . Fang Tian, Liang Tingting, Wang Yizhuo, BMC Gastroenterology . 2021,第1期

机译：结肠直肠癌Smad4基因突变的预后作用及临床病理学特征：系统评价与荟萃分析
4. Isolation of Circulating Tumor Cells from Patients with Metastatic Colorectal Cancer Using Label-Free Microfluidic Technology for Enumeration and Detection of KRAS, BRAF, PIK3CA Mutation [C] . Haiyan Emily Liu, Evelyn Kidess-Sigal, Melanie Triboulet, International Molecular Medicine Tri-Conference. . 2016

机译：使用无标记微流体技术分离转移性结肠直肠癌患者的循环肿瘤细胞进行募准和检测KRA，BRAF，PIK3CA突变
5. Glucose deprivation selects for KRAS and BRAF mutations in colorectal cancer. [D] . Yun, Jihye. 2009

机译：葡萄糖剥夺选择结直肠癌中的KRAS和BRAF突变。
6. BRAF-Mutated Colorectal Cancer Exhibits Distinct Clinicopathological Features from Wild-Type BRAF-Expressing Cancer Independent of the Microsatellite Instability Status [O] . Min Hye Jang, Sehun Kim, Dae Yong Hwang, 2017

机译：BRAF突变的结直肠癌表现出与野生型表达BRAF的癌症不同的临床病理特征而与微卫星不稳定性状态无关
7. BRAFmutation is associated with distinct clinicopathological characteristics in colorectal cancer: a systematic review and meta-analysis [O] . C. Clancy, J. P. Burke, M. F. Kalady, 2013

机译：Brafmuture与结肠直肠癌的不同临床病理特征有关：系统评价和荟萃分析

MSI status is associated with distinct clinicopathological features in BRAF mutation colorectal cancer: A systematic review and meta-analysis

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