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Sexual dysfunction and hyperprolactinemia in schizophrenia before and after six weeks of D-2/3 receptor blockade - An exploratory study

机译:在D-2/3受体封锁的六周后和后期和后期的性功能障碍和高催障症血症 - 探究性研究

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Sexual side-effects along with antipsychotic treatment may be linked to hyperprolactinemia and dopamine D-2 receptor blockade. High prevalence of sexual dysfunction in un-medicated patients challenges the notion of sexual dysfunction as merely a side-effect of antipsychotic medication. Sexual dysfunction was assessed in fifty-six initially antipsychotic-naive patients with schizophrenia using the UKU (Udvalget for Kliniske Undersogelser) questionnaire. Serum-prolactin was obtained before and after six weeks of D-2/3 receptor blockade with amisulpride. At baseline 68% of patients reported one or more items of sexual dysfunction (males > females,), but the cumulative load of sexual dysfunction was similar in males and females. After 6 weeks treatment with amisulpride (mean dose 279 mg/day), 65% of patients reported one or more items of sexual dysfunctions (females > males). There was a significant sex*time interaction on mean sexual dysfunction load. All patients developed hyperprolactinaemia, and a significant effect of time and sex was found on s-prolactin (females > males). The results support that patients with schizophrenia report high levels of sexual dysfunction before antipsychotic exposure. After treatment, sexual side-effects were more frequent in females, coinciding with pronounced serum-prolactin increases. These findings suggest sex differences in sexual dysfunction before and after antipsychotic treatment.
机译:性副作用以及抗精神病药治疗可能与高催乳素血症和多巴胺D-2受体阻滞有关。无药物患者的性功能障碍高患病率挑战性功能障碍的概念,只是抗精神病药的副作用。使用UKU(UDValget for Kliniske Undersogelser)问卷调查问卷,在56名最初抗精神病药患者中评估了性功能障碍。在用氨基丙烯酯的D-2/3受体封闭在D-2/3受体封闭的六周之前和之后获得血清 - 催乳素。在基线68%的患者报告了一种或多种性功能障碍物品(男性>女性,),但是性功能障碍的累积载荷在雄性和女性中相似。 6周后用氨基丙烯雷德治疗(平均剂量279毫克/天),65%的患者报告了一种或多种性功能障碍(女性>男性)。有一个重要的性别*时间相互作用对平均性功能障碍负载。所有患者均发育过脱硫血症,在S-rolactin(女性>男性)上发现了时间和性别的显着效果。结果支持精神分裂症患者在抗精神病患者之前报告高水平的性功能障碍。在治疗后,女性中的性副作用更频繁,伴随着明显的血清催乳素增加。这些研究结果表明抗精神病治疗前后性功能障碍的性差异。

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