Reduced prefrontal hemodynamic response in adult attention‐deficit hyperactivity disorder as measured by near‐infrared spectroscopy

摘要

Aim Recent developments in nearinfrared spectroscopy (NIRS) have enabled noninvasive clarification of brain functions in psychiatric disorders. In pediatric attentiondeficit hyperactivity disorder (ADHD), reduced prefrontal hemodynamic responses have been observed with NIRS repeatedly. However, there are few studies of adult ADHD by multichannel NIRS. Therefore, in this study, we used multichannel NIRS to examine the characteristics of prefrontal hemodynamic responses during the Stroop ColorWord Task (SCWT) in adult ADHD patients and in age and sexmatched control subjects. Methods Twelve treatmentna飗e adults with ADHD and 12 age and sexmatched healthy control subjects participated in the present study after giving consent. We used 24channel NIRS to measure the oxygenated hemoglobin (oxyHb) changes at the frontal lobes of participants during the SCWT. We compared the oxyHb changes between adults with ADHD and control subjects byt tests with Bonferroni correction.Results During the SCWT, the oxyHb changes observed in the ADHD group were significantly smaller than those in the control group in channels 11, 16, 18, 21, 22, 23, and 24, corresponding to the prefrontal cortex. At channels 16, 21, 23, and 24 of the ADHD group, there were negative correlations between the symptomatic severity and the oxyHb changes. Conclusion The present study suggests that adults with ADHD have reduced prefrontal hemodynamic response as measured by NIRS.