Relationship between histogram metrics of pharmacokinetic parameters of DCE-MRI and histological phenotype in breast cancer

摘要

Background: To investigate the correlation between quantitative pharmacokinetic parameters and clinicopathological prognostic biomarkers including estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and MiB1 (Ki-67) in patients with breast cancer, the image histogram analysis was performed on dynamic contrast-enhanced magnetic resonance imaging (DCEMRI).