Comprehensive assessment of cytochromes P450 and transporter genetics with endoxifen concentration during tamoxifen treatment

Marcath Lauren A.; Deal Allison M.; Van Wieren Emily; Danko William; Walko Christine M.; Ibrahim Joseph G.; Weck Karen E.; Jones David R.; Desta Zeruesenay; McLeod Howard L.; Carey Lisa A.; Irvin William J. Jr.; Hertz Daniel L.

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Comprehensive assessment of cytochromes P450 and transporter genetics with endoxifen concentration during tamoxifen treatment

机译：在三氧肟治疗过程中综合评估细胞色素P450和肠毒素浓度的转运遗传群

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Objectives Tamoxifen bioactivation to endoxifen is mediated primarily by CYP2D6; however, considerable variability remains unexplained. Our aim was to perform a comprehensive assessment of the effect of genetic variation in tamoxifen-relevant enzymes and transporters on steady-state endoxifen concentrations.

机译：目的毒素的生物活化至肠藻蛋白主要由CYP2D6介绍; 但是，相当大的可变性仍然无法解释。我们的目的是对稳态内毒素浓度进行遗传变异的遗传变异效果的全面评估。

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来源
《Pharmacogenetics and genomics》 |2017年第11期|共8页
作者
Marcath Lauren A.; Deal Allison M.; Van Wieren Emily; Danko William; Walko Christine M.; Ibrahim Joseph G.; Weck Karen E.; Jones David R.; Desta Zeruesenay; McLeod Howard L.; Carey Lisa A.; Irvin William J. Jr.; Hertz Daniel L.;
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作者单位

Univ Michigan Coll Pharm Dept Clin Pharm 428 Church St Room 3054 Ann Arbor MI 48109 USA;

Univ N Carolina Lineberger Comprehens Canc Ctr Chapel Hill NC 27599 USA;

Univ Michigan Coll Pharm Dept Clin Pharm 428 Church St Room 3054 Ann Arbor MI 48109 USA;

Univ Michigan Coll Pharm Dept Clin Pharm 428 Church St Room 3054 Ann Arbor MI 48109 USA;

DeBartolo Family Personalized Med Inst Moffitt Canc Ctr Tampa FL USA;

Univ N Carolina Lineberger Comprehens Canc Ctr Chapel Hill NC 27599 USA;

Univ N Carolina Lineberger Comprehens Canc Ctr Chapel Hill NC 27599 USA;

Indiana Univ Dept Clin Pharmacol Indianapolis IN 46204 USA;

Indiana Univ Dept Clin Pharmacol Indianapolis IN 46204 USA;

DeBartolo Family Personalized Med Inst Moffitt Canc Ctr Tampa FL USA;

Univ N Carolina Lineberger Comprehens Canc Ctr Chapel Hill NC 27599 USA;

Univ N Carolina Lineberger Comprehens Canc Ctr Chapel Hill NC 27599 USA;

Univ Michigan Coll Pharm Dept Clin Pharm 428 Church St Room 3054 Ann Arbor MI 48109 USA;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
CYP2C9; CYP2D6; endoxifen; pharmacogenomics; season; tamoxifen;

机译：CYP2C9;CYP2D6;endoxifen;药物替昔胶;季节;Tamoxifen;

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专利

1. Comprehensive assessment of cytochromes P450 and transporter genetics with endoxifen concentration during tamoxifen treatment [J] . Marcath Lauren A., Deal Allison M., Van Wieren Emily, Pharmacogenetics and genomics . 2017,第11期

机译：在三氧肟治疗过程中综合评估细胞色素P450和肠毒素浓度的转运遗传群
2. The Influences of Adherence to Tamoxifen and CYP2D6 Pharmacogenetics on Plasma Concentrations of the Active Metabolite (Z)-Endoxifen in Breast Cancer [J] . Industrial and organizational psychology . 2020,第2期

机译：在乳腺癌中，粘附对Tamoxifen和Cym2D6药物obsegens血浆浓度的影响
3. The influences of adherence to tamoxifen and CYP2D6 pharmacogenetics on plasma concentrations of the active metabolite (Z)-endoxifen in breast cancer [J] . Intelligence: A Multidisciplinary Journal . 2020,第期

机译：在乳腺癌中，粘附对Tamoxifen和Cym2D6药物obsegens血浆浓度的影响
4. Structure-based design and analysis of cytochrome P450 inhibitors for the treatment of prostate cancer [C] . M. Emre Ozdemir, I. Halil Kavakli, Metin Turkay International Conference on Bioinformatics and Computational Biology . 2006

机译：基于结构的细胞色素P450抑制剂治疗前列腺癌的设计与分析
5. A Mass Balance Field Study of the Phytoremediation of Trichloroethylene with Transgenic Poplars Genetically Modified with Cytochrome P450 2E1. [D] . Legault, Emily K. 2013

机译：用细胞色素P450 2E1基因修饰的转基因杨树对三氯乙烯进行植物修复的质量平衡现场研究。
6. Comprehensive assessment of cytochromes P450 and transporter genetics with endoxifen concentration during tamoxifen treatment [O] . Lauren Marcath, Allison M Deal, Emily Van Wieren, -1

机译：他莫昔芬治疗期间细胞内色素P450和转运蛋白遗传学与内皮西芬浓度的综合评估
7. Comprehensive assessment of cytochromes P450 and transporter genetics with endoxifen concentration during tamoxifen treatment [O] . Lauren A. Marcath, Allison M. Deal, Emily Van Wieren, 2017

机译：在三氧肟治疗过程中综合评估细胞学P450和肠胃浓度的转运遗传算法

Comprehensive assessment of cytochromes P450 and transporter genetics with endoxifen concentration during tamoxifen treatment

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