Steroidal glycosides from the bulbs of Lilium speciosum

摘要

Steroidal glycosides (1-21), including eight new spirostanol glycosides (1-8)and a new cholestane glycoside (9), were isolated from the bulbs of Lilium speciosum . The structures of the new compounds were determined based on spectroscopic data analysis and hydrolytic cleavage reactions. The isolated compounds and their aglycones (1a , 8a , and 9a)were evaluated for their cytotoxicity against HL-60 human acute promyelocytic leukemia cells and A549 human lung carcinoma cells. Compounds 12 and 21 exhibited moderate cytotoxic activity toward HL-60 and A549 cells, with IC50 values of 6.9 mu M and 5.1 mu M against HL-60 cells, and 7.6 mu M and 4.4 mu M against A549 cells, respectively. Compound 20 only showed moderate cytotoxicity toward A549 cells, with an IC50 value of 6.7 mu M.