The Origin of 7 alpha-Hydroxy-Dehydroepiandrosterone and Its Physiological Role: a History of Discoveries

摘要

Nearly 60 years has elapsed since the first isolation and identification of 7 alpha-hydroxy-dehydroepiandrosterone, and in that time much information has been gained on its occurrence, metabolism, ontogeny, immunomodulatory activity, cell proliferation, cortisol control in local tissues and neuroactivity. Additional knowledge about this steroid may elucidate its role in obesity, neurodegenerative disturbances such as Alzheimer's disease, or psychiatric disorders such as schizophrenia or depression. This review aims to provide a comprehensive summary of the available literature on 7 alpha-hydroxydehydroepiandrosterone.