Towards therapeutic drug monitoring of everolimus in cancer? Results of an exploratory study of exposure-effect relationship

Deppenweiler Marine; Falkowski Sabrina; Saint-Marcoux Franck; Monchaud Caroline; Picard Nicolas; Laroche Marie-Laure; Tubiana-Mathieu Nicole; Venat-Bouvet Laurence; Marquet Pierre; Woillard Jean-Baptiste

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Towards therapeutic drug monitoring of everolimus in cancer? Results of an exploratory study of exposure-effect relationship

机译：对癌症血尿症患者的治疗药物监测？曝光效应关系的探索性研究结果

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Introduction: Therapeutic drug monitoring (TDM) of everolimus is not performed in oncology and no trough level (C-0) target has been yet defined. The aim of this study was to determine everolimus C-0 target for toxicity and efficacy.

机译：介绍：everolimus的治疗药物监测（TDM）未在肿瘤学中进行，并且尚未定义槽级（C-0）目标。本研究的目的是确定艾蒿C-0的毒性和疗效目标。

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来源
《Pharmacological research: The official journal of The Italian Pharmacological Society》 |2017年第2017期|共7页
作者
Deppenweiler Marine; Falkowski Sabrina; Saint-Marcoux Franck; Monchaud Caroline; Picard Nicolas; Laroche Marie-Laure; Tubiana-Mathieu Nicole; Venat-Bouvet Laurence; Marquet Pierre; Woillard Jean-Baptiste;
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作者单位

Univ Hosp Limoges Dept Pharmacol Toxicol &

Pharmacovigilance Limoges France;

Univ Hosp Limoges Dept Oncol Limoges France;

Univ Hosp Limoges Dept Pharmacol Toxicol &

Pharmacovigilance Limoges France;

Univ Hosp Limoges Dept Pharmacol Toxicol &

Pharmacovigilance Limoges France;

Univ Hosp Limoges Dept Pharmacol Toxicol &

Pharmacovigilance Limoges France;

Univ Hosp Limoges Dept Pharmacol Toxicol &

Pharmacovigilance Limoges France;

Univ Hosp Limoges Dept Oncol Limoges France;

Univ Hosp Limoges Dept Oncol Limoges France;

Univ Hosp Limoges Dept Pharmacol Toxicol &

Pharmacovigilance Limoges France;

Univ Hosp Limoges Dept Pharmacol Toxicol &

Pharmacovigilance Limoges France;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
Everolimus; Cancer; Therapeutic drug monitoring; Exposure-effect relationship; Trough level; Efficacy-toxicity target;

机译：everolimus;癌症;治疗药物监测;曝光效应关系;槽水平;疗效毒性目标;

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专利

1. Towards therapeutic drug monitoring of everolimus in cancer? Results of an exploratory study of exposure-effect relationship [J] . Deppenweiler Marine, Falkowski Sabrina, Saint-Marcoux Franck, Pharmacological research: The official journal of The Italian Pharmacological Society . 2017,第期

机译：对癌症血尿症患者的治疗药物监测？曝光效应关系的探索性研究结果
2. Therapeutic Drug Monitoring of Oral Anticancer Drugs: The Dutch Pharmacology Oncology Group-Therapeutic Drug Monitoring Protocol for a Prospective Study [J] . Groenland Stefanie L., van Eerden Ruben A. G., Verheijen Remy B., Therapeutic Drug Monitoring . 2019,第5期

机译：口腔抗癌药物治疗药物监测：荷兰药理学肿瘤学群治疗药物监测议定书
3. Crossreactivity of isolated everolimus metabolites with the Innofluor Certican immunoassay for therapeutic drug monitoring of everolimus. [J] . Strom T, Haschke M, Boyd J, Therapeutic Drug Monitoring . 2007,第6期

机译：分离出的依维莫司代谢物与依维氟Certican免疫测定的交叉反应性，用于依维莫司的治疗药物监测。
4. Feasibility study of paper-based surface enhanced Raman spectroscopy of tear fluids for onsite therapeutic drug monitoring [C] . Yokoyama Moe, Nishimura Takahiro, Yamada Kenji, World Automation Congress . 2014

机译：纸基表面增强拉曼光谱对泪液进行现场治疗药物监测的可行性研究
5. Exploratory study of gold nanoshell as a therapeutic thermal ablation agent for cancer treatment using laboratory and animal tissue phantoms. [D] . Rathore, Yajuvendra. 2009

机译：使用实验室和动物组织体模对金纳米壳作为治疗性热消融剂进行癌症治疗的探索性研究。
6. Long-term Cross-validation of Everolimus Therapeutic Drug Monitoring Assays: The Zortracker Study [O] . B Schniedewind, S Niederlechner, JL Galinkin, -1

机译：依维莫司治疗药物监测方法的长期交叉验证：Zortracker研究
7. Therapeutic drug monitoring of everolimus: a consensus report [O] . Shipkova M., Hesselink D., Holt D., 2016

机译：依维莫司的治疗药物监测：共识报告
8. Therapeutic Value of PLK1 Knockdown in Combination with Prostate Cancer Drugs in PIM-1 Overexpressing Prostate Cancer Cells. [R] . Roh, M. 2014

机译：pLK1敲除与过表达前列腺癌细胞的pIm-1中前列腺癌药物联合治疗的价值。

Towards therapeutic drug monitoring of everolimus in cancer? Results of an exploratory study of exposure-effect relationship

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