Effective treatment of Fox-Fordyce disease with pulsed dye laser

摘要

Dear Sir, Fox-Fordyce disease (FFD) is a rare inflammatory disorder of apocrine sweat glands, which is clinically characterized by smooth, uniform, firm, folliculocentric, yellow skin-colored papules on apocrine gland-bearing areas (1). Etiology of FFD is still unclear, but epidemiologic data support the role of hormonal component (1, 2). FFD is a treatment-resistant disease, and no certain treatment method has been proven to be curative. Topical and intralesional glucocorticoids, topical and systemic retinoids, topical clindamycin, topical pime-crolimus cream, benzoyl peroxide, oral contraceptives, oral isotretinoin, and ablative lasers have been reported with varying efficacy portion. In recalcictrant cases, mechanical destruction or removal of the apocrine glands can be offered. Pulsed dye laser is a gold standard treatment method for vascular lesions which was first used in the treatment of telangiectatic chronic erythema in 1996 (3). Today, we can use this laser in many different indications both in vascular, inflammatory, and tumoral etiology (4, 5). Effect of this laser has not been reported in the literature before. We want to present a young female patient with Fox- Fordyce disease with good response to pulsed dye laser.