~18F-Sodium Fluoride PET/ CTand PET/MR Imaging of Bone and Joint Disorders

摘要

Sodium Fluoride F 18 (~18F-NaF) is a positron-emitting radiotracer that was first introduced in 1962 for skeletal scintigraphy. Its clinical use was limited, however, at that time mainly due to a short half-life of 109.74 minutes and tracer characteristics that were less ideal for conventional gamma cameras. Thus, it had been largely replaced in the late 1970s by ~99mTc-labeled diphosphonates, which showed optimal characteristics for conventional gamma-based scintigraphy.