Novel sulfur and selenium-containing antioxidants: Synthesis and evaluation of their GPx-like activity

摘要

New linear and cyclic chalcogen-containing compounds have been synthesized exploiting the reactivity of bis(trimethylsilyl)selenicle with strained heterocycles. A simple and efficient procedure allowed a selective access to beta-functionalized selenides, diselenides and dithiaselenepanes under mild conditions. Antioxidant catalytic activity, of these compounds was investigated in the reaction of hydrogen peroxide with dithiothreitol (DTTred), According to this assay, some of the synthesized structures exhibited a remarkable glutathione peroxidase (GPx)-like activity.