Nanopores: Electronic Tools for Single-molecule Biophysics and Bio-nanotechnologies

摘要

Nanopores - nanometer-sized holes in ultrathin membranes - are driving a revolution in the life sciences and in medicine, where high-performance detection systems must achieve greater speed, sensitivity and accuracy. In this short review, we present the principles of solid-state nanopore-based single-molecule detection and discuss the challenges, which must be overcome in order for solid-state nanopores to transition from a leading candidate under development to a disruptive technology.