Effects of Moisture-Induced Crystallization on the Aerosol Performance of Spray Dried Amorphous Ciprofloxacin Powder Formulations

Shetty Nivedita; Zeng Lingfei; Mangal Sharad; Nie Haichen; Rowles Matthew R.; Guo Rui; Han Youngwoo; Park Joon Hyeong; Zhou Qi (Tony)

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Effects of Moisture-Induced Crystallization on the Aerosol Performance of Spray Dried Amorphous Ciprofloxacin Powder Formulations

机译：水分诱导结晶对喷雾干燥无定形环丙沙星粉体制剂的气溶胶性能的影响

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Purpose This study aims to investigate the influence of different storage humidity conditions on crystallization and aerosol performance of inhalable spray dried amorphous powder formulations (Ciprofloxacin hydrochloride as the model drug).

机译：目的本研究旨在探讨不同储存湿度条件对可吸入喷雾干燥无定形粉体制剂的结晶和气溶胶性能的影响（作为模型药物的环丙沙星盐酸盐）。

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《Pharmaceutical research》 |2018年第1期|共13页
作者
Shetty Nivedita; Zeng Lingfei; Mangal Sharad; Nie Haichen; Rowles Matthew R.; Guo Rui; Han Youngwoo; Park Joon Hyeong; Zhou Qi (Tony);
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作者单位

Purdue Univ Coll Pharm Dept Ind &

Phys Pharm 575 Stadium Mall Dr W Lafayette IN 47907 USA;

Purdue Univ Coll Pharm Dept Ind &

Phys Pharm 575 Stadium Mall Dr W Lafayette IN 47907 USA;

Purdue Univ Coll Pharm Dept Ind &

Phys Pharm 575 Stadium Mall Dr W Lafayette IN 47907 USA;

Teva Pharmaceut 145 Brandywine Pkwy W Chester PA 19380 USA;

Curtin Univ Dept Phys &

Astron Bentley WA 6102 Australia;

Purdue Univ Coll Pharm Dept Ind &

Phys Pharm 575 Stadium Mall Dr W Lafayette IN 47907 USA;

Purdue Univ Coll Pharm Dept Ind &

Phys Pharm 575 Stadium Mall Dr W Lafayette IN 47907 USA;

Purdue Univ Birck Nanotechnol Ctr 1205 West State St W Lafayette IN 47907 USA;

Purdue Univ Coll Pharm Dept Ind &

Phys Pharm 575 Stadium Mall Dr W Lafayette IN 47907 USA;

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原文格式 PDF
正文语种 eng
中图分类生药学（天然药物学）;
关键词
aerosol performance; amorphous powder; crystallization; dry powder inhaler; particle surface roughness; spray drying; storage humidity;

机译：气溶胶性能;无定形粉末;结晶;干粉吸入器;颗粒表面粗糙度;喷雾干燥;储存湿度;

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专利

1. Effects of Moisture-Induced Crystallization on the Aerosol Performance of Spray Dried Amorphous Ciprofloxacin Powder Formulations (vol 35, 2018) [J] . Shetty Nivedita, Zeng Lingfei, Mangal Sharad, Pharmaceutical research . 2018,第3期

机译：水分诱导结晶对喷雾干燥无定形环丙沙星粉末制剂的气溶胶性能的影响（Vol 35,2018）
2. Protection of hydrophobic amino acids against moisture-induced deterioration in the aerosolization performance of highly hygroscopic spray-dried powders [J] . Jiaqi Yu, Hak-Kim Chan, Thomas Gengenbach, European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V . 2017,第期

机译：保护疏水性氨基酸对高吸湿喷雾干燥粉末的雾化性能下的水分诱导的劣化
3. Aerosolization characteristics of dry powder inhaler formulations for the excipient enhanced growth (EEG) application: Effect of spray drying process conditions on aerosol performance [J] . SonY.-J., WorthLongestP., HindleM. International Journal of Pharmaceutics . 2013,第1a2期

机译：用于赋形剂增强生长（EEG）应用的干粉吸入器制剂的气雾化特性：喷雾干燥工艺条件对气雾剂性能的影响
4. CFD Analysis of the Aerosolization of Carrier-based Dry Powder Inhaler Formulations [C] . Qi (Tony) Zhou, Zhenbo Tong, Patricia Tang, International Conference on Micromechanics of Granular Media . 2013

机译：CFD分析载体干粉吸入器配方的雾化
5. Effects of particle surface modifications on dry powder formulation performances. [D] . Schueller, Laurent Bruno. 2005

机译：颗粒表面改性对干粉配方性能的影响。
6. Effects of Moisture-Induced Crystallization on the Aerosol Performance of Spray Dried Amorphous Ciprofloxacin Powder Formulations [O] . Nivedita Shetty, Lingfei Zeng, Sharad Mangal, -1

机译：水分诱导的结晶对喷雾干燥的无定形环丙沙星粉末制剂气雾性能的影响
7. Effects of Moisture-Induced Crystallization on the Aerosol Performance of Spray Dried Amorphous Ciprofloxacin Powder Formulations [O] . Nivedita Shetty, Lingfei Zeng, Sharad Mangal, 2018

机译：水分诱导结晶对喷雾干燥无定形环丙沙星粉制剂的气溶胶性能的影响

Effects of Moisture-Induced Crystallization on the Aerosol Performance of Spray Dried Amorphous Ciprofloxacin Powder Formulations

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