Closed-Loop Doluisio (Colon, Small Intestine) and Single-Pass Intestinal Perfusion (Colon, Jejunum) in Rat-Biophysical Model and Predictions Based on Caco-2

Lozoya-Agullo Isabel; Gonzalez-Alvarez Isabel; Zur Moran; Fine-Shamir Noa; Cohen Yael; Markovic Milica; Garrigues Teresa M.; Dahan Arik; Gonzalez-Alvarez Marta; Merino-Sanjuan Matilde; Bermejo Marival; Avdeef Alex

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Closed-Loop Doluisio (Colon, Small Intestine) and Single-Pass Intestinal Perfusion (Colon, Jejunum) in Rat-Biophysical Model and Predictions Based on Caco-2

机译：基于Caco-2的大鼠生物物理模型和预测中的闭环多洛米酶（结肠，小肠）和单通过肠道灌注（结肠，Jejunum）

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Purpose The effective rat intestinal permeability (P-eff) was deconvolved using a biophysical model based on parameterized paracellular, aqueous boundary layer, transcellular permeabilities, and the villus-fold surface area expansion factor.

机译：目的，使用基于参数化荚膜，横瓣膜，横细胞渗透率和绒毛折叠表面区域膨胀因子的生物物理模型对有效大鼠肠道渗透率（p-eff）进行解泛。

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来源
《Pharmaceutical research》 |2018年第1期|共23页
作者
Lozoya-Agullo Isabel; Gonzalez-Alvarez Isabel; Zur Moran; Fine-Shamir Noa; Cohen Yael; Markovic Milica; Garrigues Teresa M.; Dahan Arik; Gonzalez-Alvarez Marta; Merino-Sanjuan Matilde; Bermejo Marival; Avdeef Alex;
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作者单位

Miguel Hernandez Univ Pharmacokinet &

Pharmaceut Technol Alicante Spain;

Miguel Hernandez Univ Pharmacokinet &

Pharmaceut Technol Alicante Spain;

Ben Gurion Univ Negev Fac Hlth Sci Dept Clin Pharmacol Beer Sheva Israel;

Ben Gurion Univ Negev Fac Hlth Sci Dept Clin Pharmacol Beer Sheva Israel;

Ben Gurion Univ Negev Fac Hlth Sci Dept Clin Pharmacol Beer Sheva Israel;

Ben Gurion Univ Negev Fac Hlth Sci Dept Clin Pharmacol Beer Sheva Israel;

Univ Valencia Pharmacokinet &

Pharmaceut Technol Valencia Spain;

Ben Gurion Univ Negev Fac Hlth Sci Dept Clin Pharmacol Beer Sheva Israel;

Miguel Hernandez Univ Pharmacokinet &

Pharmaceut Technol Alicante Spain;

Univ Valencia Pharmacokinet &

Pharmaceut Technol Valencia Spain;

Miguel Hernandez Univ Pharmacokinet &

Pharmaceut Technol Alicante Spain;

In ADME Res 1732 First Ave 102 New York NY 10128 USA;

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原文格式 PDF
正文语种 eng
中图分类生药学（天然药物学）;
关键词
aqueous boundary layer permeability; Caco-2; dynamic range window (DRW); paracellular permeability; rat colon and small intestinal perfusion methods;

机译：水性边界层渗透性;Caco-2;动态范围窗口（DRW）;肺细胞间渗透性;大鼠结肠和小肠灌注方法;

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专利

1. Closed-Loop Doluisio (Colon, Small Intestine) and Single-Pass Intestinal Perfusion (Colon, Jejunum) in Rat-Biophysical Model and Predictions Based on Caco-2 [J] . Lozoya-Agullo Isabel, Gonzalez-Alvarez Isabel, Zur Moran, Pharmaceutical research . 2018,第1期

机译：基于Caco-2的大鼠生物物理模型和预测中的闭环多洛米酶（结肠，小肠）和单通过肠道灌注（结肠，Jejunum）
2. In-situ intestinal rat perfusions for human F-abs prediction and BCS permeability class determination: Investigation of the single-pass vs. the Doluisio experimental approaches [J] . Lozoya-Agullo Isabel, Zur Moran, Wolk Omri, International Journal of Pharmaceutics . 2015,第1a2期

机译：用于人F-abs预测和BCS渗透性类别确定的原位小肠大鼠灌流：单程与Doluisio实验方法的研究
3. In-situ intestinal rat perfusions for human F-abs prediction and BCS permeability class determination: Investigation of the single-pass vs. the Doluisio experimental approaches [J] . Lozoya-Agullo Isabel, Zur Moran, Wolk Omri, International Journal of Pharmaceutics . 2015,第1a2期

机译：用于人F-ABS预测的原位肠道灌注和BCS渗透课程测定：对单通率与Doluisio实验方法的调查
4. A Multilayer Monte Carlo Model for the Investigation of Optical Path and Penetration Depth at Different Perfusion States of the Colon [C] . Z. Patel, S. Chatterjee, M. A. Thaha, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2019

机译：用于研究结肠不同灌注状态下光路和穿透深度的多层蒙特卡洛模型
5. Constructing gene expression based prognostic models to predict recurrence and lymph node metastasis in colon cancer. [D] . Mettu, Ramakanth Reddy. 2008

机译：构建基于基因表达的预后模型，以预测结肠癌的复发和淋巴结转移。
6. Intestinal absorption of forsythoside A in in situ single-pass intestinal perfusion and in vitro Caco-2 cell models [O] . Wei Zhou, Liu-qing Di, Juan Wang, 2012

机译：原位单次肠道灌流和体外Caco-2细胞模型中邻苯二甲酸酯A的肠道吸收
7. Intestinal absorption of forsythoside A in in situ single-pass intestinal perfusion and in vitro Caco-2 cell models [O] . Wei Zhou, Liu-qing Di, Juan Wang, 2012

机译：肠道吸收于原位单通过肠灌注和体外Caco-2细胞模型

Closed-Loop Doluisio (Colon, Small Intestine) and Single-Pass Intestinal Perfusion (Colon, Jejunum) in Rat-Biophysical Model and Predictions Based on Caco-2

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