Potential Synthetic Adaptogens. II. Synthesis and Pharmacological Activity of New Conformationally Labile Bromantane Analogs, N -[(Adamantan-1-YL)Methyl]-4-Bromoanilines

摘要

New structural analogs of bromantane with greater conformational lability than the prototype were synthesized. Their physiological activity profiles were assessed in vivo . It was found that the analogs could be prepared under much milder conditions than bromantane and that their biological activity profiles dependedstrongly on the nature of adamantane substitution.