Synthesis and Biological Activity of 2-Mercapto-7,10-Dimethyl-3H-Spiro[Benzo[H]Quinazoline-5,1'-Cyclopentane]-4(6H)-One from Ethyl 4'-Amino-5',8'-Dimethyl-1'H-Spiro[Cyclopentane-1,2'-Naphthalene]-3'-Carboxylate

摘要

A synthetic method for 7,10-dimethyl-2-thioxo-2,3-dihydro-1H-spiro[benzo[h]quinazoline-5,1'-cyclopentane]- 4(6H)-one from ethyl 4'-amino-5',8'-dimethyl-1'-H-spiro[cyclopentane-1,2'-naphthalene]-3'-carboxylate was developed. Reaction of the spirobenzo[h]quinazoline with various alkyl(benzyl) halides synthesized a novel series of spirobenzo[h]quinazolines containing methyl substituents on the benzene ring. The antidepressant, anticonvulsant, and antibacterial activities of the synthesized spirobenzo[h]quinazolines were investigated.