POTENTIAL SYNTHETIC ADAPTOGENS. II. SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF NEW CONFORMATIONALLY LABILE BROMANTANE ANALOGS, N-[(ADAMANTAN-1-YL) METHYL]-4-BROMOANILINES

摘要

New structural analogs of bromantane with greater conformational lability than the prototype were synthesized. Their physiological activity profiles were assessed in vivo. It was found that the analogs could be prepared under much milder conditions than bromantane and that their biological activity profiles depended strongly on the nature of adamantane substitution.