SYNTHESIS, CHARACTERIZATION, ANTIBACTERIALAND ANTIFUNGAL ACTIVITY OF THIENOPYRIMIDINES, AND TRIAZOLOTHIENOPYRIMIDINES

摘要

A series of novel triazole fused tetracyclic thienopyrimidines (III - X) were synthesized from the corresponding precursor 5-amino-4-cyano-3-methylthiophene-2-carboxylic acid ethyl ester I. The precursor were in turn prepared via the Gewald reaction. Structures of all the newly synthesized compounds were characterized by spectral and analytical data. All the tested compounds displayed promising antibacterial and antifungal activities.