Mutations in voltage-gated sodium channels from pyrethroid resistant salmon lice (Lepeophtheirus salmonis)

摘要

BACKGROUNDParasitic salmon lice (Lepeophtheirus salmonis) cause high economic losses in Atlantic salmon farming. Pyrethroids, which block arthropod voltage-gated sodium channels (Na(v)1), are used for salmon delousing. However, pyrethroid resistance is common in L. salmonis. The present study characterized Na(v)1 homologues in L. salmonis in order to identify channel mutations associated to resistance, called kdr (knockdown) mutations.