Impaired Mobilization of Endothelial Progenitor Cells in Acute Lung Injury/Acute Respiratory Distress Syndrome: Inhibition of an Endogenous Mechanism of Lung Repair*

摘要

Acute lung injury and acute respiratory distress syndrome (ALI/ARDS) are important contributors to morbidity and mortality in the ICU for both children and adults. Over the four^lecades since the clinical features of ARDS were described by Ashbaugh and colleagues (1), the pathophysiology of ALI has been well characterized, and the major molecular and cellular pathways that lead to the neutrophilic alveolar inflammation, epithelial and endofhelial damage, deregulated coagulation, and instigation of nbroproliferation have been largely defined (2). However, despite these advances, therapies to specifically block the initiation or progression of lung injury have been woefully disappointing.