Monodispersed β‐Glycerophosphate‐Decorated Bioactive Glass Nanoparticles Reinforce Osteogenic Differentiation of Adipose Stem Cells and Bone Regeneration In Vivo

摘要

Abstract >Design and development of highly bioactive nanoscale biomaterials with enhanced osteogenic differentiation on adipose stem cells is rather important for bone regeneration and attracting much attention. Herein, monodispersed glycerophosphate‐decorated bioactive glass nanoparticles (BGN@GP) are designed and their effect is investigated on the osteogenic differentiation of adipose mesenchymal stem cells (ADMSCs) and in vivo bone regeneration. The surface‐modified BGN@GP can be efficiently taken by ADMSCs and shows negligible cytotoxicity. The in vitro results reveal that BGN@GP significantly enhances the alkaline phosphatase activity and calcium biominerialization of ADMSCs either under normal or osteoinductive medium as compared to BGNs. Further studies find that the osteogenic genes and proteins including Runx2 and Bsp in ADMSCs are significantly improved by BGN@GP even under normal culture medium. The in vivo animal experiment confirms that BGN@GP significantly promotes the new bone formation in a rat skull defect model. This study suggests that bioactive small molecule decorating is an efficient strategy to improve the osteogenesis capacity of inorganic ceramics nanomaterials. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> >高度生物活性纳米级生物材料的设计和开发具有增强的脂肪酸干细胞的成骨分化，对骨再生具有相当重要的重要性，并吸引了很多关注。在此，设计了单分散的甘油磷酸盐装饰的生物活性玻璃纳米颗粒（BGN @ GP），并研究其对脂肪间充质干细胞（ADMSCs）和体内骨再生的骨质发生分化。可以通过ADMSCS有效地拍摄表面改性的BGN @ GP，并且显示出可忽略的细胞毒性。体外结果表明，与BGN相比，BGN @ GP在正常或骨诱导介质下显着增强了ACMSCs的碱性磷酸酶活性和钙生物化化。进一步的研究发现，即使在正常培养基下，BGN @ GP也显着改善了在ADMSCS中的骨质发生基因和蛋白质在ADMS中的蛋白质显着改善。体内动物实验证实，BGN @ GP显着促进了大鼠颅骨缺陷模型中的新骨形成。该研究表明，生物活性小分子装饰是改善无机陶瓷纳米材料的成骨容量的有效策略。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-28901/'>《Particle & Particle Systems Characterization: Measurement and Description of Particle Properties and Behavior in Powders and Other Disperse Systems》</a> <b style="margin: 0 2px;">|</b><span>2020年第4期</span><b style="margin: 0 2px;">|</b><span>共10页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/6960.html" title="特种结构材料">特种结构材料;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=adipose stem cells&option=203" rel="nofollow">adipose stem cells;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=bioactive biomaterials&option=203" rel="nofollow">bioactive biomaterials;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=glass nanoparticles&option=203" rel="nofollow">glass nanoparticles;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=osteogenic differentiation&option=203" rel="nofollow">osteogenic differentiation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=surface modification&option=203" rel="nofollow">surface modification;</a> </p> <div class="translation"> 机译：脂肪干细胞;生物活性生物材料;玻璃纳米粒子;骨质发生分化;表面改性; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704024384485.html">Monodispersed β‐Glycerophosphate‐Decorated Bioactive Glass Nanoparticles Reinforce Osteogenic Differentiation of Adipose Stem Cells and Bone Regeneration In Vivo</a> <b>[J]</b> . <span> <a 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style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：鉴定源自分化脂肪的成年干细胞和使源自脂肪分化的成年干细胞分化的化合物的方法。鉴别源自源自分化脂肪的成年干细胞未分化脂肪的成年干细胞，并选择源自脂肪的细胞来自成年脂肪干细胞群的成年干细胞 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130400746248.html">CELL THERAPEUTIC FOR REGENERATING BONE TISSUE OF CANINE ANIMALS USING OSTEOGENIC DIFFERENTIATION OF BROWN FAT TISSUE-DERIVED MESENCHYMAL STEM CELL AND METHOD FOR MANUFACTURING SAME</a> <b>[P]</b> . <span> 外国专利：  KR20200045744A </span> <span> . 2020-05-06</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：利用棕色脂肪组织源性间充质干细胞的骨源性分化来再生犬类动物骨组织的细胞治疗剂及其制造方法 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130408818551.html">METHOD FOR INDUCING DIFFERENTIATION OF ADIPOSE STEM CELLS INTO NEURAL STEM CELLS, NEURONS AND GAMMA-AMINOBUTYRIC ACID NEURONS, AND METHOD FOR INDUCING DIFFERENTIATION OF HUMAN STEM CELLS THAT SECRETE LARGE AMOUNTS OF GROWTH FACTORS FROM HUMAN BONE MARROW DERIVED MESENCHYMAL STEM CELLS</a> <b>[P]</b> . <span> 外国专利：  WO2017179767A1 </span> <span> . 2017-10-19</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：诱导脂肪干细胞分化为神经干细胞的方法将脂肪干细胞分化为神经干细胞，神经元和γ-氨基丁酸神经元的方法，以及诱导人干细胞分化的方法 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" 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