Prophylactic administration of fibrinogen concentrate in a pregnant woman with congenital hypofibrinogenemia and a positive obstetric history of severe bleeding in previous cesarean section

摘要

Introduction: Congenital disorders of fibrinogen are uncommon and affect either the quantity (afibrinogenemia and hypofibrinogenemia) or/and the quality (dysfibrinogenemia/ hypodysfibrinogenemia) of circulating fibrinogen. They consist hereditary diseases, associated mainly with bleeding episodes.In a significant number of patients clinical manifestations, however, include thrombosis; in the case of dysfibrinogenemia 10-20% of patients are reported with thrombotic complications.