CD109 promotes the tumorigenic ability and metastatic motility of pancreatic ductal adenocarcinoma cells

Hatsuzawa Yuuri; Yamaguchi Kazunori; Takanashi Tomoka; Sato Ikuro; Tamai Keiichi; Mochizuki Mai; Iwai Wataru; Wakui Yuta; Abue Makoto; Yamamoto Kuniharu; Yasuda Jun; Mizuma Masamichi; Unno Michiaki; Sugamura Kazuo

首页> 外文期刊>Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.] >CD109 promotes the tumorigenic ability and metastatic motility of pancreatic ductal adenocarcinoma cells

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CD109 promotes the tumorigenic ability and metastatic motility of pancreatic ductal adenocarcinoma cells

机译：CD109促进胰腺导管腺癌细胞的致瘤能力和转移性运动

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Background: Accumulating evidence indicates that CD109, a glycosylphosphatidylinositol-anchored glycoprotein, is highly expressed in human epithelial carcinomas of multiple organs including the pancreas, but its functional role in carcinoma development has not yet been fully clarified. The aim of this study was to investigate the role of CD109 in the malignancy of pancreatic ductal adenocarcinoma (PDAC).

机译：背景技术累积证据表明CD109是糖基磷脂酰肌醇锚定糖蛋白，在包括胰腺的多个器官的人上皮癌中高度表达，但其在癌症发育中的功能作用尚未完全澄清。本研究的目的是探讨CD109在胰腺导管腺癌（PDAC）恶性肿瘤中的作用。

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来源
《Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.]》 |2020年第3期|共8页
作者
Hatsuzawa Yuuri; Yamaguchi Kazunori; Takanashi Tomoka; Sato Ikuro; Tamai Keiichi; Mochizuki Mai; Iwai Wataru; Wakui Yuta; Abue Makoto; Yamamoto Kuniharu; Yasuda Jun; Mizuma Masamichi; Unno Michiaki; Sugamura Kazuo;
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作者单位

Miyagi Canc Ctr Res Inst Div Mol &

Cellular Oncol 47-1 Nodayama Natori Miyagi 9811293 Japan;

Miyagi Canc Ctr Res Inst Div Mol &

Cellular Oncol 47-1 Nodayama Natori Miyagi 9811293 Japan;

Miyagi Canc Ctr Res Inst Div Mol &

Cellular Oncol 47-1 Nodayama Natori Miyagi 9811293 Japan;

Tohoku Univ Dept Canc Sci Grad Sch Med Sendai Miyagi 9808575 Japan;

Tohoku Univ Dept Canc Sci Grad Sch Med Sendai Miyagi 9808575 Japan;

Tohoku Univ Dept Canc Sci Grad Sch Med Sendai Miyagi 9808575 Japan;

Miyagi Canc Ctr Dept Gastroenterol Natori Miyagi 9811293 Japan;

Miyagi Canc Ctr Dept Gastroenterol Natori Miyagi 9811293 Japan;

Miyagi Canc Ctr Dept Gastroenterol Natori Miyagi 9811293 Japan;

Tohoku Med &

Pharmaceut Univ Dept Surg Sendai Miyagi 9838536 Japan;

Miyagi Canc Ctr Res Inst Div Mol &

Cellular Oncol 47-1 Nodayama Natori Miyagi 9811293 Japan;

Tohoku Univ Dept Surg Grad Sch Med Sendai Miyagi 9808575 Japan;

Tohoku Univ Dept Surg Grad Sch Med Sendai Miyagi 9808575 Japan;

Miyagi Canc Ctr Res Inst Div Mol &

Cellular Oncol 47-1 Nodayama Natori Miyagi 9811293 Japan;

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正文语种 eng
中图分类消化系及腹部疾病;
关键词
CD109; Pancreatic cancer; Metastasis; PANC-1 cells;

机译：CD109;胰腺癌;转移;Panc-1细胞;

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专利

1. CD109 promotes the tumorigenic ability and metastatic motility of pancreatic ductal adenocarcinoma cells [J] . Hatsuzawa Yuuri, Yamaguchi Kazunori, Takanashi Tomoka, Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.] . 2020,第3期

机译：CD109促进胰腺导管腺癌细胞的致瘤能力和转移性运动
2. Galectin-1 secreted by activated stellate cells in pancreatic ductal adenocarcinoma stroma promotes proliferation and invasion of pancreatic cancer cells: an in vitro study on the microenvironment of pancreatic ductal adenocarcinoma. [J] . Xue X, Lu Z, Tang D, Pancreas . 2011,第6期

机译：胰腺导管腺癌基质中星状细胞活化分泌的Galectin-1促进胰腺癌细胞的增殖和侵袭：胰导管腺癌微环境的体外研究。
3. Upregulated long noncoding RNA LINC01296 indicates a dismal prognosis for pancreatic ductal adenocarcinoma and promotes cell metastatic properties by affecting EMT [J] . Yuan Qihua, Zhang Yuxia, Feng Lijun, Journal of cellular biochemistry. . 2019,第1期

机译：上调的长不应RNA LINC01296表明胰腺导管腺癌的令人沮丧的预后，通过影响EMT来促进细胞转移性
4. Real-time and non-invasive quantitative phase imaging of pancreatic ductal adenocarcinoma cell mechanical properties [C] . D Gillies, W Gamal, M Canel, Optical Elastography and Tissue Biomechanics VI . 2019

机译：胰腺导管腺癌细胞力学特性的实时和非侵入性定量成像
5. MMP-7 modulates the transition of normal pancreatic acinar cells to metaplastic ducts associated with the neoplastic epithelium of pancreatic ductal adenocarcinoma [D] . Johnson, Johnny 2007

机译：MMP-7调节正常胰腺腺泡细胞向与胰腺导管腺癌的肿瘤上皮相关的化生导管的过渡
6. Pancreatic Ductal Adenocarcinoma Cell Secreted Extracellular Vesicles Containing Ceramide-1-Phosphate Promote Pancreatic Cancer Stem Cell Motility [O] . Norbert Kuc, Allison Doermann, Carolyn Shirey, -1

机译：胰导管腺癌细胞分泌的含有神经酰胺-1-磷酸的细胞外囊泡促进胰腺癌干细胞运动。
7. Pancreatic ductal adenocarcinoma cell secreted extracellular vesicles containing ceramide-1-phosphate promote pancreatic cancer stem cell motility [O] . Norbert Kuc, Allison Doermann, Carolyn Shirey, 2018

机译：胰腺导管腺癌细胞分泌的含有神经酰胺-1-磷酸酯的细胞外囊泡促进胰腺癌干细胞运动

CD109 promotes the tumorigenic ability and metastatic motility of pancreatic ductal adenocarcinoma cells

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