Safety and efficacy of long-term use of sodium oxybate for narcolepsy with cataplexy in routine clinical practice

Drakatos Panagis; Lykouras Dimosthenis; DAncona Grainne; Higgins Sean; Gildeh Nadia; Macavei Raluca; Rosenzweig Ivana; Steier Joerg; Williams Adrian J.; Muza Rexford; Kent Brian D.; Leschziner Guy

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Safety and efficacy of long-term use of sodium oxybate for narcolepsy with cataplexy in routine clinical practice

机译：在常规临床实践中对鼻腔内氧巢钠的安全性和功效

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Background: Sodium oxybate is licensed in Europe for the treatment of narcolepsy with cataplexy in adults. The aim of this study was to assess the efficacy and safety of sodium oxybate in clinical practice in patients with narcolepsy and cataplexy refractory to other treatments.

机译：背景：氧毒剂钠在欧洲许可，用于治疗成人的尾剂分泌物。本研究的目的是评估羟基酸钠在鼻神经产病患者临床实践中的疗效和安全性与其他治疗难治性的患者。

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来源
《Sleep medicine》 |2017年第2017期|共5页
作者
Drakatos Panagis; Lykouras Dimosthenis; DAncona Grainne; Higgins Sean; Gildeh Nadia; Macavei Raluca; Rosenzweig Ivana; Steier Joerg; Williams Adrian J.; Muza Rexford; Kent Brian D.; Leschziner Guy;
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作者单位

Guys Hosp Sleep Disorders Ctr Great Maze Pond London SE1 9RT England;

Guys Hosp Sleep Disorders Ctr Great Maze Pond London SE1 9RT England;

Guys Hosp Sleep Disorders Ctr Great Maze Pond London SE1 9RT England;

Guys Hosp Sleep Disorders Ctr Great Maze Pond London SE1 9RT England;

Guys Hosp Sleep Disorders Ctr Great Maze Pond London SE1 9RT England;

Guys Hosp Sleep Disorders Ctr Great Maze Pond London SE1 9RT England;

Guys Hosp Sleep Disorders Ctr Great Maze Pond London SE1 9RT England;

Guys Hosp Sleep Disorders Ctr Great Maze Pond London SE1 9RT England;

Guys Hosp Sleep Disorders Ctr Great Maze Pond London SE1 9RT England;

Guys Hosp Sleep Disorders Ctr Great Maze Pond London SE1 9RT England;

Guys Hosp Sleep Disorders Ctr Great Maze Pond London SE1 9RT England;

Guys Hosp Sleep Disorders Ctr Great Maze Pond London SE1 9RT England;

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正文语种 eng
中图分类神经病学与精神病学;
关键词
Sodium oxybate; Narcolepsy; Cataplexy; Adverse effects;

机译：氧毒剂钠;鼻腔;毒性;不良反应;

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专利

1. Safety and efficacy of long-term use of sodium oxybate for narcolepsy with cataplexy in routine clinical practice [J] . Drakatos Panagis, Lykouras Dimosthenis, DAncona Grainne, Sleep medicine . 2017,第期

机译：在常规临床实践中对鼻腔内氧巢钠的安全性和功效
2. A DOUBLE-BLIND, PLACEBO-CONTROLLED, RANDOMIZED-WITHDRAWAL, MULTICENTER STUDY OF THE EFFICACY AND SAFETY OF SODIUM OXYBATE IN PEDIATRIC SUBJECTS WITH NARCOLEPSY WITH CATAPLEXY [J] . Plazzi G., Ruoff C., Lecendreux M., Sleep medicine . 2017,第期

机译：一种双盲，安慰剂对照，随机戒断，多中心研究小儿动物鼻腔氧氢钠氧巢钠的疗效和安全性研究
3. A 12-week open-label, multicenter study evaluating the safety and patient-reported efficacy of sodium oxybate in patients with narcolepsy and cataplexy [J] . Mamelak Mortimer, Swick Todd, Emsellem Helene, Sleep medicine . 2015,第1期

机译：一项为期12周的开放标签，多中心研究，评估了羟丁酸钠在发作性睡病和瘫痪患者中的安全性和患者报告的疗效
4. IMMEDIATE AND LONG-TERM EFFICACY AND SAFETY OF PHOTODYNAMIC THERAPY WITH PHOTOLON? (FOTOLON?) - A SEVEN-YEAR CLINICAL EXPERIENCE [C] . Yuri P. Istomin, Michael A. Kaplan, Siarhei. V. Shliakhtsin, World congress of the International Photodynamic Association . 2009

机译：使用光子进行光动力疗法的近期和长期疗效以及安全性？（FOTOLON？）-七年临床经验
5. Joint modeling time-to-event and longitudinal data using Markov chain Monte Carlo methods with application to the Proscar(TM) long-term efficacy and safety study. [D] . He, Weili. 2002

机译：使用Markov链蒙特卡罗方法对事件时间和纵向数据进行联合建模，并将其应用于Proscar（TM）的长期疗效和安全性研究。
6. Safety and efficacy of long-term use of sodium oxybate for narcolepsy with cataplexy in routine clinical practice [O] . Panagis Drakatos, Dimosthenis Lykouras, Grainne DAncona, -1

机译：在常规临床实践中长期使用羟丁酸钠进行发作性睡病伴猝死的安全性和有效性
7. Safety and efficacy of long-term use of sodium oxybate for narcolepsy with cataplexy in routine clinical practice [O] . Drakatos Panagis, Lykouras Dimosthenis, DAncona Grainne, 2017

机译：在常规临床实践中长期使用羟丁酸钠进行发作性睡病伴猝死的安全性和有效性

Safety and efficacy of long-term use of sodium oxybate for narcolepsy with cataplexy in routine clinical practice

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