Moderate-to-severe obstructive sleep apnea is associated with subclinical myocardial injury and impaired hemodynamics in pulmonary hypertension patients

摘要

Background: The clinical significance of obstructive sleep apnea (OSA) in pulmonary hypertension (PH) patients remains unclear. We investigated the hemodynamics and serum troponin T concentrations associated with OSA in PH patients. Methods: Cross-sectional study was performed on data from 97 clinically stable PH patients. Using overnight sleep study, we evaluated apneae-hypopnea index (AHI) and divided patients into two groups: none-to-mild OSA (AHI < 15/h, N = 81) and moderate-to-severe OSA (AHI >= 15/h, N = 16). Clinical, hemodynamic, and laboratory data were compared with OSA severity.