A NOVEL, ORALLY AVAILABLE OREXIN 2 RECEPTOR-SELECTIVE AGONIST, TAK-994, SHOWS WAKE-PROMOTING EFFECTS FOLLOWING CHRONIC DOSING IN AN OREXIN-DEFICIENT NARCOLEPSY MOUSE MODEL

Ishikawa T.; Suzuki M.; Kimura H.

首页> 外文期刊>Sleep >A NOVEL, ORALLY AVAILABLE OREXIN 2 RECEPTOR-SELECTIVE AGONIST, TAK-994, SHOWS WAKE-PROMOTING EFFECTS FOLLOWING CHRONIC DOSING IN AN OREXIN-DEFICIENT NARCOLEPSY MOUSE MODEL

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A NOVEL, ORALLY AVAILABLE OREXIN 2 RECEPTOR-SELECTIVE AGONIST, TAK-994, SHOWS WAKE-PROMOTING EFFECTS FOLLOWING CHRONIC DOSING IN AN OREXIN-DEFICIENT NARCOLEPSY MOUSE MODEL

机译：一种新颖的口服orexin 2受体选择性激动剂Tak-994，显示出在缺乏缺乏的鼻腔模型中慢性给药后慢性给药的唤醒促进作用

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《Sleep》 |2020年第1期|共1页
作者
Ishikawa T.; Suzuki M.; Kimura H.;
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Takeda Pharmaceut Co Ltd Fujisawa Kanagawa Japan;

Takeda Pharmaceut Co Ltd Fujisawa Kanagawa Japan;

Takeda Pharmaceut Co Ltd Fujisawa Kanagawa Japan;

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原文格式 PDF
正文语种 eng
中图分类人体生理学;
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1. A NOVEL, ORALLY AVAILABLE OREXIN 2 RECEPTOR-SELECTIVE AGONIST, TAK-994, SHOWS WAKE-PROMOTING EFFECTS FOLLOWING CHRONIC DOSING IN AN OREXIN-DEFICIENT NARCOLEPSY MOUSE MODEL [J] . Ishikawa T., Suzuki M., Kimura H. Sleep . 2020,第Suppla1期

机译：一种新颖的口服orexin 2受体选择性激动剂Tak-994，显示出在缺乏缺乏的鼻腔模型中慢性给药后慢性给药的唤醒促进作用
2. TAK-925, an orexin 2 receptor-selective agonist, shows robust wake-promoting effects in mice [J] . Yukitake Hiroshi, Fujimoto Tatsuhiko, Ishikawa Takashi, Pharmacology, Biochemistry and Behavior . 2019,第期

机译：Tak-925，一种orexin 2受体选择性激动剂，显示在小鼠中稳健的唤醒效果
3. 0055 An Orexin 2 Receptor-selective Agonist, TAK-925, Ameliorates Narcolepsy-like Symptoms and Obesity in Orexin/ataxin-3 Transgenic Mice [J] . Kimura Haruhide, Ishikawa Takashi, Yukitake Hiroshi, Sleep . 2019,第Supplementa1期

机译：0055 Orexin 2受体选择性激动剂TAK-925可改善Orexin / ataxin-3转基因小鼠的发作性睡病症状和肥胖症
4. Assessing metabolic profiles in chimeric PXB mouse with humanized livers following oral dosing of troglitazone. [C] . Alan Barnes, Neil J Loftus, Kirsten Hobby, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：在口服给药后嵌合PXB小鼠中的代谢型材在口服给药后的杂化肝脏。
5. Mechanisms of action and effects of chronic high dose exposure to the GnRH agonist deslorelin. [D] . Edwards, Brian S. 2014

机译：长期高剂量暴露于GnRH激动剂deslorelin的作用机理和影响。
6. Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models [O] . Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Hiromu Tominaga, 2017

机译：非肽2型Orexin受体激动剂可改善小鼠模型中的发作性睡病综合症症状
7. 0002 An Orexin 2 Receptor-selective Agonist, TAK-925, Shows Robust Wake-promoting Effects In Mice And Non-human Primates [O] . H Yukitake, T Ishikawa, A Suzuki, 2018

机译：0002一种orexin 2受体选择性激动剂TAK-925，显示了小鼠和非人类灵长类动物的稳健唤醒效果
8. Initial Submission: The Effects of Styrene on Mouse Lung Following Oral Dosing, with Cover Letter Dated 8/17/1999 [R] . 1999

机译：初步提交：口服给药后苯乙烯对小鼠肺的影响，封面信函日期为8/17/1999

A NOVEL, ORALLY AVAILABLE OREXIN 2 RECEPTOR-SELECTIVE AGONIST, TAK-994, SHOWS WAKE-PROMOTING EFFECTS FOLLOWING CHRONIC DOSING IN AN OREXIN-DEFICIENT NARCOLEPSY MOUSE MODEL

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