The effect of statins on the recurrence rate of atrial fibrillation after catheter ablation: A meta-analysis

摘要

Background To more precisely evaluate the effect of statins on patients with atrial fibrillation (AF) after catheter ablation, we performed a meta-analysis of published studies. Methods Results We searched PubMed, EMBASE, and Cochrane Library for all relevant published articles from the date of inception to April 2017. Odds ratios (OR) and 95% confidence intervals (CIs) were then calculated and pooled using a random-effects model. Statistical heterogeneity was evaluated using the I-2 statistic. Nine studies with a total of 1,607 patients were included in the analysis. Overall, statins did not reduce the recurrence rate of AF after catheter ablation (OR 0.81, 95% CI 0.59-1.10, P = 0.18). However, in the subgroup analysis, the randomized control trial (RCT) group significantly reduced the recurrence of AF (OR 0.47, 95% CI 0.30-0.75, P = 0.001). Conversely, the retrospective cohort study subgroup also had a negative result (OR 1.03, 95% CI 0.78-1.36, P = 0.82). Conclusions Statin use was associated with a significantly lower AF recurrence rate in RCTs but not in the whole analysis and the observational studies.