Recent Advances in Cutaneous T-cell Lymphoma Diagnostic and Prognostic Considerations

摘要

This review describes the latest advances in the diagnosis of cutaneous T-cell lymphoma focusing on the most clinically useful features introduced since the publication of the World Health Organization revision in 2017, Clinical entities described include mycosis fungoides, Sezary syndrome, lymphomatoid papulosis, primary cutaneous anaplastic large cell lymphoma, primary cutaneous gamma delta T-cell lymphoma, primary cutaneous acral CD8~+ T-cell lymphoma, primary cutaneous CD4~+ small/medium T-cell lymphopro-liferative disorder, and hydroa-vacciniforme-like lymphoproliferative disorder. Distinguishing histo-logic clues to diagnosis are discussed, and important molecular advances are described. Key prognostic indicators that may assist clinicians with timely and appropriate management options are presented.