Mangosteen extract for short-term pain management Preclinical approach and pilot clinical investigation on volunteers with soft tissue pain

摘要

Soft tissue pain is a common and debilitating disorder linked to a wide range of unhealthy conditions, mainly involving inflammatory processes. Although frequently prescribed to manage inflammatory conditions and attendant pain, non-steroidal anti-inflammatory drugs (NSAIDs) are nevertheless associated with side and unwanted effects. Accordingly, providing safe and natural alternatives is a current challenge. In this study, an extract of mangosteen rich in alpha- and gamma-mangostins is demonstrated to significantly decrease production of the inflammation marker, tumor necrosis factor-alpha (TNF-alpha), in a murine model of inflammation, and to significantly reduce soft tissue pain in volunteers during a clinical investigation.