Alterations of DNA methylation profile in proximal jejunum potentially contribute to the beneficial effects of gastric bypass in a diabetic rat model

Liu Haijun; Zhang Hong; Wang Xiao; Yu Xuemei; Hu Cheng; Zhang Xueli

首页> 外文期刊>Surgery for obesity and related diseases: official journal of the American Society for Bariatric Surgery >Alterations of DNA methylation profile in proximal jejunum potentially contribute to the beneficial effects of gastric bypass in a diabetic rat model

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Alterations of DNA methylation profile in proximal jejunum potentially contribute to the beneficial effects of gastric bypass in a diabetic rat model

机译：近端Jejunum中DNA甲基化谱的改变可能导致胃旁路在糖尿病大鼠模型中的有益作用

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Background: The foregut theory posits that the proximal small intestine plays an important role in the improvement of type 2 diabetes (T2D) after Roux-en-Y gastric bypass (RYGB).

机译：背景：前述近似小肠在Roux-Zh-Y胃旁路（RygB）之后在改善2型糖尿病（T2D）中发挥着重要作用的前述理论。

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来源
《Surgery for obesity and related diseases: official journal of the American Society for Bariatric Surgery》 |2019年第8期|共8页
作者
Liu Haijun; Zhang Hong; Wang Xiao; Yu Xuemei; Hu Cheng; Zhang Xueli;
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作者单位

Southern Med Univ Shanghai Fengxian Cent Hosp Dept Gen Surg 6600 Nanfeng Rd Shanghai 201499;

Shanghai Jiao Tong Univ Affiliated Sixth Peoples Hosp Shanghai Diabet Inst 600 Yishan Rd;

Shanghai Jiao Tong Univ Affiliated Sixth Peoples Hosp Shanghai Diabet Inst 600 Yishan Rd;

Southern Med Univ Shanghai Fengxian Cent Hosp Dept Endocrinol Shanghai Peoples R China;

Southern Med Univ Shanghai Fengxian Cent Hosp Dept Gen Surg 6600 Nanfeng Rd Shanghai 201499;

Southern Med Univ Shanghai Fengxian Cent Hosp Dept Gen Surg 6600 Nanfeng Rd Shanghai 201499;

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原文格式 PDF
正文语种 eng
中图分类外科学;
关键词
Type 2 diabetes; Roux-en-Y gastric bypass; DNA methylation; Proximal jejunum;

机译：2型糖尿病;Roux-Zh-Y胃旁路;DNA甲基化;近端Jejunum;

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专利

1. Alterations of DNA methylation profile in proximal jejunum potentially contribute to the beneficial effects of gastric bypass in a diabetic rat model [J] . Liu Haijun, Zhang Hong, Wang Xiao, Surgery for obesity and related diseases: official journal of the American Society for Bariatric Surgery . 2019,第8期

机译：近端Jejunum中DNA甲基化谱的改变可能导致胃旁路在糖尿病大鼠模型中的有益作用
2. ALTERATIONS IN DNA METHYLATION MIGHT EXPLAIN THE IMPAIRED BONE REMODELING IN DIABETIC PATIENTS [J] . Maghbooli Z., Hossein-Nezhad A., Sadeghi M., Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA . 2017,第Suppla1期

机译：DNA甲基化的改变可以解释糖尿病患者的骨质重塑受损
3. DNA methyltransferase 3A isoform b contributes to repressing E-cadherin through cooperation of DNA methylation and H3K27/H3K9 methylation in EMT-related metastasis of gastric cancer. [J] . He Cui, Ying Hu, Didi Guo, Oncogene . 2018,第32期

机译：DNA甲基转移酶3a同种型B通过DNA甲基化和H3K27 / H3K9甲基化的EMT相关转移来抑制E-Cadherin。
4. Targeted profiling of 5-(hydroxy)methylcytosine in genomic DNA from human livers: Next-generation sequencing of target enriched DNA reveals unexpectedly high interindividual variability of cytosine methylation and hydroxymethylation [C] . Ivanov Maxim, Ingelman-Sundberg Magnus, Kals Mart, IEEE International Conference on Bioinformatics and Biomedicine . 2014

机译：人类肝脏基因组DNA中5-（羟）甲基胞嘧啶的靶向分析：富含靶DNA的下一代测序揭示了胞嘧啶甲基化和羟甲基化的意料之外的高度个体差异
5. Epigenome-Wide Profiling of DNA Methylation and Somatic Alterations in Breast Cancer Subgroups [D] . Chen, Youdinghuan (David). 2020

机译：外延甲基化和乳腺癌亚组的细胞改变的外延型分析
6. Beneficial effects of proximal intestinal bypass reconstruction on glucose metabolism in a type 2 diabetes animal model: a possible reconstruction strategy for diabetic gastric cancer patients [O] . Soo Min Ahn, Woo Jin Hyung 2021

机译：近端肠旁路重建对2型糖尿病动物模型葡萄糖代谢的有益效果：糖尿病胃癌患者可能的重建策略
7. Beneficial effects of proximal intestinal bypass reconstruction on glucose metabolism in a type 2 diabetes animal model: a possible reconstruction strategy for diabetic gastric cancer patients [O] . Soo Min Ahn, Woo Jin Hyung 2021

机译：近端肠旁路重建对2型糖尿病动物模型葡萄糖代谢的有益效果：糖尿病胃癌患者可能的重建策略

Alterations of DNA methylation profile in proximal jejunum potentially contribute to the beneficial effects of gastric bypass in a diabetic rat model

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