Radiation Sensitization of HNSCC Cells by the dual PI3K / mTOR Inhibitor BEZ235 as a function of the Cell Cycle

Brandt F. W.; Balzer V; Dreffke K.; Wittig A.; Dikomey E.; Arenz A.; Schoetz U.; Engenhart-Cabillic R.

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Radiation Sensitization of HNSCC Cells by the dual PI3K / mTOR Inhibitor BEZ235 as a function of the Cell Cycle

机译：双PI3K / mTOR抑制剂BEZ235作为细胞周期的辐射敏化

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《Strahlentherapie und Onkologie》 |2018年第1期|共1页
作者
Brandt F. W.; Balzer V; Dreffke K.; Wittig A.; Dikomey E.; Arenz A.; Schoetz U.; Engenhart-Cabillic R.;
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作者单位

Philipps Univ Marburg Klin Strahlentherapie &

Radioonkol Marburg Germany;

Philipps Univ Marburg Klin Strahlentherapie &

Radioonkol Marburg Germany;

Philipps Univ Marburg Klin Strahlentherapie &

Radioonkol Marburg Germany;

Philipps Univ Marburg Klin Strahlentherapie &

Radioonkol Marburg Germany;

Philipps Univ Marburg Klin Strahlentherapie &

Radioonkol Marburg Germany;

Philipps Univ Marburg Klin Strahlentherapie &

Radioonkol Marburg Germany;

Philipps Univ Marburg Klin Strahlentherapie &

Radioonkol Marburg Germany;

Philipps Univ Marburg Klin Strahlentherapie &

Radioonkol Marburg Germany;

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正文语种 ger
中图分类放射医学;
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专利

1. Radiation Sensitization of HNSCC Cells by the dual PI3K / mTOR Inhibitor BEZ235 as a function of the Cell Cycle [J] . Brandt F. W., Balzer V, Dreffke K., Strahlentherapie und Onkologie . 2018,第Suppla1期

机译：双PI3K / mTOR抑制剂BEZ235作为细胞周期的辐射敏化
2. Significant Radiation Sensitization of HNSCC-Cell Lines by the dual PI3K/mTOR/Akt Inhibitor NVP-BEZ235 caused by Inhibition of Double-Strand Break Repair [J] . Balzer V, Arenz A., Preising S., Strahlentherapie und Onkologie . 2016,第Suppla1期

机译：双层断裂修复抑制作用的双链抑制作用的双链抑制作用抑制抑制剂NVP-BEZ235的显着辐射敏化
3. The PI3K/mTOR dual inhibitor NVP‐BEZ235 stimulates mutant p53 degradation to exert anti‐tumor effects on triple‐negative breast cancer cells [J] . Jiajing Cai, Jingruo Xia, Jiang Zou, FEBS Open Bio . 2020,第4期

机译：PI3K / mTOR双抑制剂NVP-BEZ235刺激突变体P53降解，以对三阴性乳腺癌细胞产生抗肿瘤作用
4. Combination of PI3K/Akt/mTOR inhibitors and PDT in endothelial and tumor cells. [C] . Fateye, Babasola, Chen Bin Optical methods for tumor treatment and detection: mechanisms and techniques in photodynamic therapy XX . 2011

机译：内皮细胞和肿瘤细胞中PI3K / Akt / mTOR抑制剂和PDT的组合。
5. Clinical Pharmacokinetics of the Novel Combination of BEZ235, PI3K/mTOR Inhibitor, and Everolimus, mTOR Inhibitor: Phase I Clinical Studies and Non-Clinical Mechanistic Assessment [D] . Moorthy, Ganesh P. 2015

机译：BEZ235，PI3K / mTOR抑制剂和依维莫司，mTOR抑制剂的新型组合的临床药代动力学：I期临床研究和非临床机制评估
6. The PI3K/mTOR dual inhibitor BEZ235 nanoparticles improve radiosensitization of hepatoma cells through apoptosis and regulation DNA repair pathway [O] . Xiaolong Tang, Amin Li, Chunmei Xie, 2020

机译：PI3K / mTOR双重抑制剂BEZ235纳米颗粒通过凋亡和调节DNA修复途径改善肝癌细胞的放射敏感性
7. Dual PI3K/AKT/mTOR Inhibitor BEZ235 Synergistically Enhances the Activity of JAK2 Inhibitor against Cultured and Primary Human Myeloproliferative Neoplasm Cells [O] . Warren Fiskus, Srdan Verstovsek, Taghi Manshouri, 2013

机译：双PI3K / AKT / MTOR抑制剂BEZ235协同增强JAK2抑制剂对培养和原发性髓鳞状肿瘤细胞的活性

Radiation Sensitization of HNSCC Cells by the dual PI3K / mTOR Inhibitor BEZ235 as a function of the Cell Cycle

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