A multicenter, open-label, comparative study of B-cell depletion therapy with Rituximab for systemic sclerosis-associated interstitial lung disease

Daoussis Dimitrios; Melissaropoulos Konstantinos; Sakellaropoulos Georgios; Antonopoulos Ioannis; Markatseli Theodora E.; Simopoulou Theodora; Georgiou Panagiotis; Andonopoulos Andrew P.; Drosos Alexandros A.; Sakkas Lazaros; Liossis Stamatis-Nick

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A multicenter, open-label, comparative study of B-cell depletion therapy with Rituximab for systemic sclerosis-associated interstitial lung disease

机译：蓖麻油干燥 - 相关间质肺病蓖麻油蛋白B细胞耗水治疗的多中心，开放标签对比较研究

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Objectives: Rituximab (RTX) may favorably affect lung function and skin fibrosis in patients with systemic sclerosis (SSc). We aimed to assess long-term efficacy and safety of RTX in SSc compared to standard treatment.

机译：目的：Rituximab（RTX）可能有利地影响系统性硬化症（SSC）患者的肺功能和皮肤纤维化。与标准治疗相比，我们旨在评估SSC中RTX的长期疗效和安全性。

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《Seminars in Arthritis and Rheumatism》 |2017年第5期|共7页
作者
Daoussis Dimitrios; Melissaropoulos Konstantinos; Sakellaropoulos Georgios; Antonopoulos Ioannis; Markatseli Theodora E.; Simopoulou Theodora; Georgiou Panagiotis; Andonopoulos Andrew P.; Drosos Alexandros A.; Sakkas Lazaros; Liossis Stamatis-Nick;
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作者单位

Univ Patras Med Sch Div Rheumatol Patras Univ Hosp Dept Internal Med Patras 26504 Greece;

Univ Patras Med Sch Div Rheumatol Patras Univ Hosp Dept Internal Med Patras 26504 Greece;

Univ Patras Dept Med Phys Patras Greece;

Univ Patras Med Sch Div Rheumatol Patras Univ Hosp Dept Internal Med Patras 26504 Greece;

Univ Ioannina Med Sch Ioannina Univ Hosp Dept Rheumatol Ioannina Greece;

Univ Thessaly Med Sch Larissa Univ Hosp Dept Rheumatol Larisa Greece;

Agios Andreas Dist Hosp Dept Rheumatol Patras Greece;

Univ Patras Med Sch Div Rheumatol Patras Univ Hosp Dept Internal Med Patras 26504 Greece;

Univ Ioannina Med Sch Ioannina Univ Hosp Dept Rheumatol Ioannina Greece;

Univ Thessaly Med Sch Larissa Univ Hosp Dept Rheumatol Larisa Greece;

Univ Patras Med Sch Div Rheumatol Patras Univ Hosp Dept Internal Med Patras 26504 Greece;

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原文格式 PDF
正文语种 eng
中图分类免疫性疾病;
关键词
Scleroderma; Systemic sclerosis; Rituximab; Interstitial lung disease; Fibrosis; B cells;

机译：硬皮病;全身硬化;Rituximab;间质肺病;纤维化;B细胞;

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1. A multicenter, open-label, comparative study of B-cell depletion therapy with Rituximab for systemic sclerosis-associated interstitial lung disease [J] . Daoussis Dimitrios, Melissaropoulos Konstantinos, Sakellaropoulos Georgios, Seminars in Arthritis and Rheumatism . 2017,第5期

机译：蓖麻油干燥 - 相关间质肺病蓖麻油蛋白B细胞耗水治疗的多中心，开放标签对比较研究
2. B LYMPHOCYTE DEPLETION IN SYSTEMIC SCLEROSIS-ASSOCIATED INTERSTITIAL LUNG DISEASE AFTER TREATMENT WITH STANDARD AND LOW DOSES OF RITUXIMAB [J] . Ananjeva L., Alexankin A., Desinova O., Clinical and experimental rheumatology . 2014,第2Suppla81期

机译：B淋巴细胞消耗在全身硬化相关的间质肺病治疗后用标准和低剂量的Rituximab
3. Successful experience of rituximab therapy for systemic sclerosis-associated interstitial lung disease with concomitant systemic lupus erythematosus [J] . SumidaH., AsanoY., TamakiZ., The Journal of dermatology . 2014,第5期

机译：利妥昔单抗治疗系统性硬化症相关性间质性肺疾病并发系统性红斑狼疮的成功经验
4. An open-label, multicenter, randomized,comparative, safety, efficacy, cycle control,and quality of life study of CTR 25, Alesse ,and Ortho Tri-Cyclen [C] . Victoria Davis, Brian Hauck, Sheila Dunn, World Congress on Fertility and Sterility . 2004

机译：开放标签，多中心，随机，比较，安全，疗效，循环控制和CTR 25，Alesse和Ortho Tri-Cyclen的生命研究
5. Safety and Efficacy of the Immunomodulatory Drug (IMiD) Lenalidomide in Patients with Lymphoma: Development of RU051417I - Phase I/II Open-Label Study of R-ICE (Rituximab-Ifosfamide-Carboplatin-Etoposide) with Lenalidomide [R2-ICE] in Patients with First-Relapse/Primary Refractory Diffuse Large B-Cell Lymphoma (DLBCL). [D] . Kasi, Pashtoon Murtaza. 2018

机译：免疫调节药物来那度胺在淋巴瘤患者中的安全性和有效性：RU051417I-R-ICE（利妥昔单抗-异环磷酰胺-卡铂-依托泊苷）与来那度胺[R2-ICE]的I / II期开放标签研究的进展初次复发/原发性难治性弥漫性大B细胞淋巴瘤（DLBCL）。
6. Autologous stem-cell transplantation in systemic sclerosis-associated interstitial lung disease: early action in selected patients rather than escalation therapy for all [O] . J. Spierings, Y-H. Chiu, M. Voortman, 2021

机译：系统性硬化相关间质性肺病中的自体干细胞移植：选定患者的早期作用而不是升级治疗
7. Disease frequency, patient characteristics, comorbidity outcomes and immunosuppressive therapy in systemic sclerosis and systemic sclerosis-associated interstitial lung disease: a US cohort study [O] . Qiang Li, Laura Wallace, Padmaja Patnaik, 2020

机译：疾病频率，患者特征，合并症结果和免疫抑制治疗系统硬化和系统性硬化相关性间质性肺病：美国队列研究

A multicenter, open-label, comparative study of B-cell depletion therapy with Rituximab for systemic sclerosis-associated interstitial lung disease

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