Targeted Delivery of Nucleic Acids by Folate-Containing Liposomes into KB-3-1 and HEK 293 Cells

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Targeted Delivery of Nucleic Acids by Folate-Containing Liposomes into KB-3-1 and HEK 293 Cells

机译：通过含叶酸脂质体靶向核酸，进入KB-3-1和HEK 293细胞

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Targeted cationic liposomes containing folate lipoconjugates with spacer groups of various lengths and natures were prepared; their physicochemical characteristics and their transfection activity towards KB-3-1 and HEK 293 cells were determined. Targeted delivery of plasmid DNA was studied by competitive inhibition of DNA delivery in the presence of free folic acid.

机译：制备含有各种长度和自然的间隔基团的叶酸脂肪组缀合物的靶向阳离子脂质体; 确定它们的物理化学特性及其对KB-3-1和HEK 293细胞的转染活性。通过在游离叶酸存在下通过竞争性抑制DNA递送的竞争抑制来研究质粒DNA的靶向递送。

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《Russian journal of bioorganic chemistry》 |2019年第6期|共7页
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正文语种 eng
中图分类生物化学;
关键词
cationic liposomes; targeted delivery; folate-containing lipoconjugates; folic acid; transfection; nucleic acids;

机译：阳离子脂质体;靶向递送;含叶酸的脂肪组缀合物;叶酸;转染;核酸;

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专利

1. Targeted Delivery of Nucleic Acids by Folate-Containing Liposomes into KB-3-1 and HEK 293 Cells [J] . Russian journal of bioorganic chemistry . 2019,第6期

机译：通过含叶酸脂质体靶向核酸，进入KB-3-1和HEK 293细胞
2. Folate-targeted cationic liposomes for the efficient delivery of nucleic acids into tumor cells [J] . Shmendel E., Morozova N., Zenkova M., The FEBS journal . 2014,第Suppla1期

机译：靶向叶酸的阳离子脂质体，可将核酸有效地递送至肿瘤细胞
3. Transcriptome Analysis of FEN1 Knockdown HEK293T Cell Strain Reveals Alteration in Nucleic Acid Metabolism, Virus Infection, Cell Morphogenesis and Cancer Development [J] . Liu Song-Bai, Qiu Xiu-Qin, Guo Wei-Qiang, Combinatorial chemistry & high throughput screening . 2019,第6期

机译：FEN1敲低HEK293T细胞菌株的转录组分析显示核酸代谢，病毒感染，细胞形态发生和癌症发育的变化
4. SMARTICLES? - Charge reversible liposomes for intracellular delivery of nucleic acids [C] . Gerold Endert, Stefan Fankhaenel, Steffen Panzner Controlled Release Society annual meeting . 2004

机译：SMARTICLES？ -电荷可逆脂质体用于核酸的细胞内递送
5. Do ZFX and ZNF711 Regulate the Same Genes in HEK293T Cells? [D] . Zhu, Wei 2018

机译：ZFX和ZNF711是否在HEK293T细胞中调节相同的基因？
6. Antheraea pernyi Silk Fibroin-Coated PEI/DNA Complexes for Targeted Gene Delivery in HEK 293 and HCT 116 Cells [O] . Yu Liu, Renchuan You, Guiyang Liu, 2014

机译：ther蚕丝丝蛋白包被的PEI / DNA复合物在HEK 293和HCT 116细胞中的靶向基因传递
7. Antheraea pernyi Silk Fibroin-Coated PEI/DNA Complexes for Targeted Gene Delivery in HEK 293 and HCT 116 Cells [O] . Yu Liu, Renchuan You, Guiyang Liu, 2014

机译：antheraea pernyi丝素蛋白涂层pEI / DNa复合物用于HEK 293和HCT 116细胞中的靶向基因递送

Targeted Delivery of Nucleic Acids by Folate-Containing Liposomes into KB-3-1 and HEK 293 Cells

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