Exostosin-1 enhances canonical Wnt signaling activity during chondrogenic differentiation

摘要

Objective: Exostosin-1 (Ext1) encodes a glycosyltransferase required for heparan sulfate (HS) chain elongation in HS-proteoglycan biosynthesis. HS chains serve as binding partners for signaling proteins, affecting their distribution and activity. The Wnt/beta-catenin pathway emerged as critical regulator of chondrogenesis. Yet, how EXT1 and HS affect Wnt/beta-catenin signaling during chondrogenesis remains unexplored.