Efficacy and safety of single-dose onabotulinumtoxinA in the treatment of symptoms of osteoarthritis of the knee: results of a placebo-controlled, double-blind study

McAlindon T. E.; Schmidt U.; Bugarin D.; Abrams S.; Geib T.; DeGryse R. E.; Kim K.; Schnitzer T. J.

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Efficacy and safety of single-dose onabotulinumtoxinA in the treatment of symptoms of osteoarthritis of the knee: results of a placebo-controlled, double-blind study

机译：单剂量OnaboTulinumtoxina治疗膝关节骨关节炎症状的疗效和安全性：安慰剂控制的结果，双盲研究

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摘要

Objective: To evaluate intraarticular onabotulinumtoxinA 400 U and 200 U in reducing symptoms of knee osteoarthritis (OA) in patients with nociceptive pain.

机译：目的：评价肌室OnaboTulinumtoxina 400 u和200 u，在减少痛苦疼痛患者膝关节骨关节炎（OA）的症状中。

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来源
《Osteoarthritis and cartilage》 |2018年第10期|共9页
作者
McAlindon T. E.; Schmidt U.; Bugarin D.; Abrams S.; Geib T.; DeGryse R. E.; Kim K.; Schnitzer T. J.;
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作者单位

Tufts Med Ctr Div Rheumatol Boston MA USA;

CCBR Ballerup Bioclin Res Network Ballerup Denmark;

Allergan Plc Irvine CA USA;

Allergan Plc Irvine CA USA;

Allergan Plc Irvine CA USA;

Allergan Plc Irvine CA USA;

Allergan Plc Irvine CA USA;

Northwestern Univ Feinberg Sch Med 710 N Lake Shore Dr Room 1020 Chicago IL 60611 USA;

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原文格式 PDF
正文语种 eng
中图分类骨科学（运动系疾病、矫形外科学）;
关键词
Osteoarthritis; Nociceptive pain; OnabotulinumtoxinA; Intra-articular; Placebo effect;

机译：骨关节炎;伤害性疼痛;OnaboTulinumtoxina;关节内;安慰剂效应;

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1. Efficacy and safety of single-dose onabotulinumtoxinA in the treatment of symptoms of osteoarthritis of the knee: results of a placebo-controlled, double-blind study [J] . McAlindon T. E., Schmidt U., Bugarin D., Osteoarthritis and cartilage . 2018,第10期

机译：单剂量OnaboTulinumtoxina治疗膝关节骨关节炎症状的疗效和安全性：安慰剂控制的结果，双盲研究
2. The efficacy and safety of S-flurbiprofen plaster in the treatment of knee osteoarthritis: a phase II, randomized, double-blind, placebo-controlled, dose-finding study [J] . Ikuko Yataba, Noboru Otsuka, Isao Matsushita, Journal of Pain Research . 2017,第2期

机译：S-氟比洛芬膏药治疗膝部骨关节炎的有效性和安全性：II期，随机，双盲，安慰剂对照，剂量研究
3. Efficacy and safety of 5% ibuprofen cream treatment in knee osteoarthritis. Results of a randomized, double-blind, placebo-controlled study. [J] . Trnavsky K, Fischer M, Vogtle Junkert U, The Journal of rheumatology . 2004,第3期

机译：5％布洛芬乳膏治疗膝盖骨关节炎的疗效和安全性。一项随机，双盲，安慰剂对照研究的结果。
4. MULTI-CENTER, PLACEBO-CONTROLLED, DOUBLE-BLIND, RANDOMIZED STUDY OF ORAL TOCERANIB PHOSPHATE (PALLADIATM, SU11654), A RECEPTOR TYROSINE KINASE INHIBITOR, FOR THE TREATMENT OF DOGS WITH RECURRENT MAS [C] . Cheryl L London, Carolyn J Henry, Anthony W Rusk, Annual conference of the Veterinary Cancer Society . 2008

机译：多中心，安慰剂对照，双盲，随机研究口服Toceranib磷酸盐（Palladia TM，SU11654），受体酪氨酸激酶抑制剂，用于治疗经常性MAS的狗
5. A Randomized, Double-Blind, Placebo-Controlled Crossover Trial Evaluating the Effect of Intranasal Insulin on Cognition and Emotional Processing in Individuals with Treatment-Resistant Major Depressive Disorder. [D] . Cha, Danielle Soh-Young. 2016

机译：一项随机，双盲，安慰剂对照的交叉试验评估了鼻内胰岛素对难治性重度抑郁症患者认知和情绪加工的影响。
6. The efficacy and safety of S-flurbiprofen plaster in the treatment of knee osteoarthritis: a phase II randomized double-blind placebo-controlled dose-finding study [O] . Ikuko Yataba, Noboru Otsuka, Isao Matsushita, 2017

机译：S-氟比洛芬膏药治疗膝部骨关节炎的有效性和安全性：II期随机双盲安慰剂对照剂量寻找研究
7. Efficacy and safety of single-dose onabotulinumtoxinA in the treatment of symptoms of osteoarthritis of the knee: results of a placebo-controlled, double-blind study [O] . T.E. McAlindon, U. Schmidt, D. Bugarin, 2018

机译：单剂量OnaboTulinumtoxina治疗膝关节骨关节炎症状的功效和安全性：安慰剂控制，双盲研究的结果

Efficacy and safety of single-dose onabotulinumtoxinA in the treatment of symptoms of osteoarthritis of the knee: results of a placebo-controlled, double-blind study

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