Resistin promotes CCL4 expression through toll-like receptor-4 and activation of the p38-MAPK and NF-kappa B signaling pathways: implications for intervertebral disc degeneration

Li Z.; Wang X.; Pan H.; Yang H.; Li X.; Zhang K.; Wang H.; Zheng Z.; Liu H.; Wang J.

首页> 外文期刊>Osteoarthritis and cartilage >Resistin promotes CCL4 expression through toll-like receptor-4 and activation of the p38-MAPK and NF-kappa B signaling pathways: implications for intervertebral disc degeneration

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Resistin promotes CCL4 expression through toll-like receptor-4 and activation of the p38-MAPK and NF-kappa B signaling pathways: implications for intervertebral disc degeneration

机译：抵抗蛋白通过Toll样受体-4促进CCl4表达，并激活P38-MAPK和NF-Kappa B信号通路：对椎间盘变性的影响

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Objective: This study was to investigate whether resistin induces the expression of chemokine ligand 4 (CCL4) during Intervertebral disc degeneration (IVDD) and whether toll-like receptor-4 (TLR-4) and the nuclear factor-kappa B (NF-kappa B) signaling pathway are involved in this process.

机译：目的：该研究是研究抵抗蛋白是否在椎间盘退化（IVDD）期间的趋化因子配体4（CCL4）的表达，以及是否有损失受体-4（TLR-4）和核因子-Kappa B（NF-Kappa） b）在该过程中涉及信号通路。

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来源
《Osteoarthritis and cartilage》 |2017年第2期|共10页
作者
Li Z.; Wang X.; Pan H.; Yang H.; Li X.; Zhang K.; Wang H.; Zheng Z.; Liu H.; Wang J.;
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作者单位

Sun Yat Sen Univ Affiliated Hosp 1 Dept Spine Surg Guangzhou Guangdong Peoples R China;

Sun Yat Sen Univ Guangdong Inst Gastroenterol Guangdong Prov Key Lab Colorectal &

Pelv Floor Di;

Sun Yat Sen Univ Affiliated Hosp 1 Dept Spine Surg Guangzhou Guangdong Peoples R China;

Sun Yat Sen Univ Affiliated Hosp 1 Dept Spine Surg Guangzhou Guangdong Peoples R China;

Sun Yat Sen Univ Affiliated Hosp 5 Dept Orthoped Surg Guangzhou Guangdong Peoples R China;

Sun Yat Sen Univ Affiliated Hosp 1 Dept Spine Surg Guangzhou Guangdong Peoples R China;

Sun Yat Sen Univ Affiliated Hosp 1 Dept Spine Surg Guangzhou Guangdong Peoples R China;

Sun Yat Sen Univ Affiliated Hosp 1 Dept Spine Surg Guangzhou Guangdong Peoples R China;

Sun Yat Sen Univ Affiliated Hosp 1 Dept Spine Surg Guangzhou Guangdong Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类骨科学（运动系疾病、矫形外科学）;
关键词
Resistin; Chemokine; CCL4; Intervertebral disc; Nucleus pulposus;

机译：抵抗型;趋化因子;CCL4;椎间盘;核瓜膜;

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专利

1. Resistin promotes CCL4 expression through toll-like receptor-4 and activation of the p38-MAPK and NF-kappa B signaling pathways: implications for intervertebral disc degeneration [J] . Li Z., Wang X., Pan H., Osteoarthritis and cartilage . 2017,第2期

机译：抵抗蛋白通过Toll样受体-4促进CCl4表达，并激活P38-MAPK和NF-Kappa B信号通路：对椎间盘变性的影响
2. Resistin Promotes Intervertebral Disc Degeneration by Upregulation of ADAMTS-5 Through p38 MAPK Signaling Pathway [J] . Liu Caijun, Yang Hao, Gao Fei, Spine . 2016,第18期

机译：Resistin通过p38 MAPK信号通路上调ADAMTS-5促进椎间盘退变
3. Overexpression of miR-150 Inhibits the NF-kappa B Signal Pathway in Intervertebral Disc Degeneration through Targeting P2X7 [J] . Zhang Yan, Zhang Yi-Shu, Li Xiao-Juan, Cells tissues organs . 2019,第3a4期

机译：MiR-150的过表达抑制了通过靶向P2X7的椎间盘变性中的NF-Kappa B信号途径
4. ASYMMETRIC LOADING PROMOTES EARLY SIGNS OF INTERVERTEBRAL DISC DEGENERATION IN LARGE ANIMAL ORGAN CULTURE [C] . Casey L. Korecki, Benjamin A. Walter, Karolyn E. Godburn, ASME summer bioengineering conference;SBC2009 . 2009

机译：非对称载荷促进大型动物器官培养物中椎间盘退变的早期征兆
5. A new transcriptional pathway of RelB NF-kappa B activation that promotes breast cancer invasiveness is repressed by estrogen receptor alpha. [D] . Wang, Xiaobo. 2007

机译：雌激素受体α抑制RelBNF-κB活化的新转录途径，该途径可促进乳腺癌的侵袭性。
6. TGFβ Regulates Galectin-3 Expression through Canonical Smad3 Signaling Pathway in Nucleus Pulposus Cells: Implications in Intervertebral Disc Degeneration [O] . Ye Tian, Wen Yuan, Jun Li, -1

机译：TGFβ通过规范Smad3信号通路调节髓核细胞中Galectin-3的表达：对椎间盘退变的影响。
7. Resistin promotes CCL4 expression through toll-like receptor-4 and activation of the p38-MAPK and NF-κB signaling pathways: implications for intervertebral disc degeneration [O] . Z. Li, X. Wang, H. Pan, 2017

机译：抵抗蛋白通过Toll样受体-4促进CCL4表达，并激活P38-MAPK和NF-κB信号传导途径：对椎间盘变性的影响
8. 5-Androstenediol Promotes Survival of Gamma-Irradiated Human Hematopoietic Progenitors Through Induction of NF-kappa B Activation and G-CSF Expression [R] . Xiao, M. , Inal, C. E. , Parekh, V. I. , 2007

机译：5-雄烯二醇通过诱导NF-κB活化和G-CsF表达促进γ-照射的人造血祖细胞的存活

Resistin promotes CCL4 expression through toll-like receptor-4 and activation of the p38-MAPK and NF-kappa B signaling pathways: implications for intervertebral disc degeneration

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