Synthesis, Structural Characterization, Molecular Docking of Thiophene Derived Schiff base from 4-Amino Indane and Antibacterial, DNA Binding Activities of Its Nickel and Cobalt complexes

摘要

Novel Schiff base was synthesized from 1:1 condensation of thiophene 2-carboxaldehyde and 4-Amino indane. Two solid transition metal complexes (Ni and Co) were synthesized with this ligand. The structure of ligand (2-THIO-L) and its complexes are confirmed by various spectral characterization methods. 2-THIO-L and its metal complexes are tested for antibacterial activity against Staphylococcus aureus and Escherichia coli. Both show more activity against Gram+ve than Gram-ve bacteria. Molecular docking studies of ligand (2-THIO- L) against MAP2K6 indicated that they are potential inhibitors of carcinogenic receptors. DNA binding interactions of the nickel and cobalt complexes with CT-DNA in tris hydrochloride buffer at pH-7.2 are investigated using UV-Visible spectroscopy. The binding constants are in the range of 105 M~(-1) showed hypochromism which indicate good binding affinity towards CT-DNA.