Synthesis and Elucidation of Structure of Deuterated Androsta-3,5-diene-7,17-dione

摘要

The title compound was synthesized as an internal standard for the quantitative determination of Arimistane in biological samples. [H-2(7)] Arimistane was obtained from Arimistane-d (0) by alkaline H/H-2 exchange of the D-2,D-4,D-6,D-8,D-16 protons. The location of the labels was confirmed by NMR spectroscopy. The spatial structures were studied by X-ray diffraction.