Synthesis and Study on the Potential Anticancer Activity of Phosphinolinium-Type Halide Salts

Prokofieva D. S.; Abzianidze V. V.; Bogachenkov A. S.

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Synthesis and Study on the Potential Anticancer Activity of Phosphinolinium-Type Halide Salts

机译：磷源卤化物盐潜在抗癌活性的合成研究

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Cytotoxic activity of the newly synthesized phosphinolinium-type bromide salts was evaluated against two cell lines of human origin: A549 lung adenocarcinoma and U251 glioblastoma using the sulforhodamine B assay. Compound with long alkyl chain demonstrate a stronger effect on viability of two cell lines than cysplatin.

机译：对新合成的磷源型溴化物盐的细胞毒性活性对人体源性两种细胞系评价：A549肺腺癌和U251使用苏尔磺胺胺B测定瘤。具有长烷基链的化合物表明了与两种细胞系的活力效果更强。

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《Russian Journal of General Chemistry》 |2017年第12期|共6页
作者
Prokofieva D. S.; Abzianidze V. V.; Bogachenkov A. S.;
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作者单位

ZAO Inst Expt Pharmacol Po Kuzmolovskii Str 245 St Petersburg 188663 Russia;

Fed Med Biol Agcy Chem Modeling Lab Res Inst Hyg Occupat Pathol &

Human Ecol Po Kuzmolovskii St Petersburg 188663 Russia;

St Petersburg State Univ Dept Organ Chem Inst Chem Univ Skii Pr 26 St Petersburg 198504 Russia;

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原文格式 PDF
正文语种 eng
中图分类化学;
关键词
anticancer activity; cationic lipophilic phosphonium salts; phosphinolinium-type halides;

机译：抗癌活动;阳离子亲脂性鏻盐;磷碱型卤化物;

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1. Synthesis and Study on the Potential Anticancer Activity of Phosphinolinium-Type Halide Salts [J] . Prokofieva D. S., Abzianidze V. V., Bogachenkov A. S. Russian Journal of General Chemistry . 2017,第12期

机译：磷源卤化物盐潜在抗癌活性的合成研究
2. Synthesis and biological activity evaluation of emodin quaternary ammonium salt derivatives as potential anticancer agents [J] . WangW., BaiZ., ZhangF., European Journal of Medicinal Chemistry: Chimie Therapeutique . 2012,第Null期

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4. SYNTHESIS OF CYCLIC AZA-ETHER COMPOUNDS AND STUDIES OF THEIR USE AS ANION RECEPTORS IN NON-AQUEOUS LITHIUM HALIDE SALT SOLUTIONS [C] . H. S. Lee, X. Sun, X. Q. Yang, Lithium Battery Symposium Oct 17-22, 1999, Honolulu, Hawaii . 1999

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Synthesis and Study on the Potential Anticancer Activity of Phosphinolinium-Type Halide Salts

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