Synthesis and Anticancer Activity of 1,2,4-Oxadiazole Fused Benzofuran Derivatives

摘要

Ten 1,2,4-oxadiazole fused benzofuran derivatives 11a-11j are synthesized, and their structures are confirmed by H-1 and C-13 NMR, and mass spectral data. Their anticancer activity against four human cancer cell lines, A549 (Lung), MCF7 (Breast), A375 (Melanoma), and HT-29 (Colon), by the MTT method is tested. The compounds 11b-11d, 11g, 11h, and 11j demonstrate more potent activity than the positive control.