Complexes of Cu(I) and Pd(II) with (+)-Camphor and (-)-Cavrone Thiosemicarbazones: Synthesis, Structure, and Cytotoxicity of the Pd(II) Complex

摘要

CuLCl, (CuLCl)-Cl-1, PdLCl2, and (PdLCl2)-Cl-1 complexes [L and L-1 being (+)-camphor and (-)-carvone thiosemicarbazones, respectively] have been synthesized. The structure of binuclear [Pd2L2 Cl-2(4)] complex has been determined by means of X-ray diffraction. The L-2 ligand (dehydrogenated (-)-carvone thiosemicarbazone) is coordinated via the bridging S atom to two Pd atoms. The complexes of Cu(I) and Pd(II) presumably have polynuclear and binuclear structure, respectively. These facts are in good agreement with IR and NMR spectroscopy as well as mass spectrometry data which indicate the coordination of L and L-1 ligands via the S atom. The influence of L-1 and (PdLCl2)-Cl-1 on viability of the Hep2 cell line has been studied. The (PdLCl2)-Cl-1 complex is more cytotoxic than L-1 ligand.