Biological evaluations and spectroscopic characterizations of 3-(4-ethoxyphenyl)-2-methylacrylate based organotin(IV) carboxylates derivatives

摘要

Six new organotin(IV) carboxylates, [Me2SnL2] (1), [n-Bu2SnL2] (2), [n-Oct(2)SnL(2)] (3), [Me3SnL] (4), [n-Bu3SnL] (5) and [Ph3SnL] (6), where L = 3-(4-ethoxyphenyl)-2-methylacrylate, have been synthesized and characterized by FT-IR, NMR spectroscopy and elemental analyses. The synthesized compounds were tested for in vitro antibacterial and antifungal activities. The complexes 4-6 demonstrated higher activity than the complexes 1-3. UV-Vis absorption spectroscopy indicated that the ligand and its complexes interacted with DNA via partial intercalation as well as minor groove binding.