Synthesis and Molecular Docking Studies of Novel 2-Phenyl-4-{4-[(1-phenyl-1H-1,2,3-triazol-4-yl)methoxy]benzylidene}oxazol-5(4H)-one Derivatives

摘要

2-Phenyl-4-{4-[(1-phenyl-1H-1,2,3-triazol-4-yl)methoxy]benzylidene}oxazol-5(4H)-one derivatives were synthesized by click chemistry reactions. Exploration of molecular interaction of the obtained compounds, performed through molecular docking studies with alpha-glucosidase, revealed the high docking scores (LibDock) in the range of 135.056-126.164 as compared to acarbose (136.345).