Synthesis of some substituted 5H-furo[3,2-g]chromene and benzofuran sulfonate derivatives as potent anti-HIV agents

摘要

Synthesized visnagin-9-sulfonyl esters underwent cleavage of their pyran ring upon treatment by hydroxylamine hydrochloride, hydrazine hydrate and primary amines. Reaction of visnagin-9-sulfonyl chloride 1 with alcohols or phenol gave the corresponding sulfonate derivatives 2, that were treated with hydroxylamine hydrochloride, anilines or hydrazine derivatives to give the corresponding compounds 3-5, respectively. The obtained products demonstrated potent anti-HIV activity.