Homobimetallic Organotin(IV) Complexes with Succinohydrazide Schiff Base: Synthesis, Spectroscopic Characterization, and Biological Screening

摘要

Six new bis-diorganotin(IV) complexes, [(Me2Sn)(2)L] (1), [(Et2Sn)(2)L] (2), [(n-Bu2Sn)(2)L] (3), [(Ph2Sn)(2)L] (4), [(n-Oct(2)Sn)(2)L] (5), and [(tert-C4H9)(2)Sn)(2)L] (6), where L = N (1'),N (4')-bis(2-oxidobenzylidene)-succinohydrazide, were synthesized and characterized by elemental analysis, FT-IR, NMR (H-1, C-13, and Sn-119) and Mass spectra. Spectroscopic data authenticated the existence of two pentacoordinated tin centers in all complexes, formed via coordination of bis-ONO donor sites with dialkyltin(IV) moieties. Biological screening against selected pathogenic strains of bacteria and fungi revealed high activity of compound 3 against Bacillus subtilis and Aspergillus flavis, it also exhibited highest cytotoxicity against Artemia salina.