Bis(4-nitrophenyl)phosphorylazide as a reagent for direct azidation of polyfunctional derivatives of pyrimidin-4(3De)-one

摘要

The application of bis-(4-nitrophenyl)phosphorylazide-1,8-diazabicyclo[5.4.0]undec-7-ene system for direct transformation of polyfunctional derivatives of pyrimidin-4(3H)-one in the corresponding 4-azidopyrimidines has been suggested for the first time. Using this system, novel 4-azido-6-(2,6-dihalo-alpha-methoxybenzyl)-5-methyl-2-(nitroamino)pyrimidines have been obtained in good yield under mild conditions.